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Science 1 February 1985:
Vol. 227. no. 4686, pp. 529 - 531
DOI: 10.1126/science.3917577
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Articles

Science, Vol 227, Issue 4686, 529-531
Copyright © 1985 by American Association for the Advancement of Science

articles

Experimental leprosy in three species of monkeys

RH Wolf, BJ Gormus, LN Martin, GB Baskin, GP Walsh, WM Meyers, and CH Binford

Eleven mangabey monkeys inoculated with Mycobacterium leprae developed lepromatous-type leprosy. Nine of the mangabeys were inoculated with M. leprae isolated from a mangabey with naturally acquired lepromatous leprosy. Immune function was depressed in some of these animals after dissemination of the disease. Two mangabeys developed lepromatous leprosy after inoculation with human M. leprae passaged in an armadillo. Three rhesus and three African green monkeys inoculated with mangabey-derived M. leprae also developed lepromatous leprosy. Mangabeys may be the first reported nonhuman primate model for the study of leprosy. Rhesus and African green monkeys may also prove to be reproducibly susceptible to the disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Epidemiology of Simian Immunodeficiency Virus SIVsm in U.S. Primate Centers Unravels the Origin of SIVmac and SIVstm.
C. Apetrei, A. Kaur, N. W. Lerche, M. Metzger, I. Pandrea, J. Hardcastle, S. Falkenstein, R. Bohm, J. Koehler, V. Traina-Dorge, et al. (2005)
J. Virol. 79, 8991-9005
   Abstract »    Full Text »    PDF »
Direct Inoculation of Simian Immunodeficiency Virus from Sooty Mangabeys in Black Mangabeys (Lophocebus aterrimus): First Evidence of AIDS in a Heterologous African Species and Different Pathologic Outcomes of Experimental Infection.
C. Apetrei, B. Gormus, I. Pandrea, M. Metzger, P. ten Haaft, L. N. Martin, R. Bohm, X. Alvarez, G. Koopman, M. Murphey-Corb, et al. (2004)
J. Virol. 78, 11506-11518
   Abstract »    Full Text »    PDF »
Classic AIDS in a Sooty Mangabey after an 18-Year Natural Infection.
B. Ling, C. Apetrei, I. Pandrea, R. S. Veazey, A. A. Lackner, B. Gormus, and P. A. Marx (2004)
J. Virol. 78, 8902-8908
   Abstract »    Full Text »    PDF »


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