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Science 4 January 1985:
Vol. 227. no. 4682, pp. 70 - 72
DOI: 10.1126/science.3838079
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Articles

Science, Vol 227, Issue 4682, 70-72
Copyright © 1985 by American Association for the Advancement of Science

articles

Abrupt induction of a membrane digestive enzyme by its intraintestinal substrate

AM Reisenauer and GM Gray

The regulation of amino-oligopeptidase (AOP), an intestinal brush border hydrolase essential for the surface digestion of peptide nutrients, was examined in rats in vivo. Short-term (30-minute) intraintestinal perfusion of a tetrapeptide substrate, Gly-Leu-Gly-Gly, or a synthetic substrate, leucyl-beta-naphthylamide, induced a doubling in the incorporation of [3H]leucine into the AOP in association with intracellular membranes. The subsequent conversion of AOP from nascent to mature enzyme and its membrane-associated transport to the brush border occurred at normal rates.


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