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Science 21 December 1984:
Vol. 226. no. 4681, pp. 1445 - 1447
DOI: 10.1126/science.6438800
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Articles

Science, Vol 226, Issue 4681, 1445-1447
Copyright © 1984 by American Association for the Advancement of Science

articles

Common region on chromosome 14 in T-cell leukemia and lymphoma

F Hecht, R Morgan, BK Hecht, and SD Smith

Chromosome 14 breakpoints in malignant human lymphocytes cluster on the long (q) arm near bands q11 and q32. An inversion of chromosome 14 due to breaks in q11.2 and q32.3 has now been found in a newly established childhood T-cell lymphoma cell line and confirmed in T-cell chronic lymphocytic leukemia. A translocation was also found between chromosomes 10 and 14 with a breakpoint at 14q11.2 in another T-cell lymphoma cell line. It is proposed that a proximal region on chromosome 14 in or near sub-band q11.2 is related to T-cell function. Rearrangements in this region may affect the growth of T lymphocytes and be involved in the development of T-cell malignancies.


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