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Science 14 December 1984:
Vol. 226. no. 4680, pp. 1337 - 1339
DOI: 10.1126/science.6095453
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Articles
Science, Vol 226, Issue 4680, 1337-1339
Copyright © 1984 by American Association for the Advancement of Science
JC virus enhancer-promoter active in human brain cells
S Kenney,
V Natarajan,
D Strike,
G Khoury,
and
NP Salzman
A human papovavirus, JCV, is the etiologic agent of the fatal demyelinating disease, progressive multifocal leukoencephalopathy. The JCV 98-base-pair tandem repeats, located to the late side of the viral replication origin, were shown to be a transcriptional regulatory element with enhancer-like activity in human fetal glial cells. These tandem repeats share significant homology with the 82-nucleotide rat brain-specific identifier RNA sequence.
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