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Science 14 December 1984:
Vol. 226. no. 4680, pp. 1335 - 1337
DOI: 10.1126/science.6505694
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Articles

Science, Vol 226, Issue 4680, 1335-1337
Copyright © 1984 by American Association for the Advancement of Science

articles

Activated expression of the N-myc gene in human neuroblastomas and related tumors

NE Kohl, CE Gee, and FW Alt

In neuroblastoma lines in which the N-myc gene is present as a single copy, the expression of N-myc as messenger RNA is increased relative to that in nonneuroblastoma cell lines and tumors. The increase of expression in neuroblastomas with amplified N-myc genes is the result of (i) an increase in the absolute amount of expression of each N-myc gene and (ii) an increase in the copy number of the N-myc gene. A second gene--which is amplified in many of the same lines as N-myc--is expressed to about the same degree in most human cell lines and primary tumors regardless of origin (when normalized to gene copy number). Thus, a change in the regulation of N-myc expression in neuroblastomas and certain other tumors results in greatly increased expression of each N-myc gene copy.


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