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Science 7 December 1984:
Vol. 226. no. 4679, pp. 1215 - 1217
DOI: 10.1126/science.6505689
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Articles

Science, Vol 226, Issue 4679, 1215-1217
Copyright © 1984 by American Association for the Advancement of Science

articles

Morphine analgesia potentiated but tolerance not affected by active immunization against cholecystokinin

PL Faris, CL McLaughlin, CA Baile, JW Olney, and BR Komisaruk

Administration of cholecystokinin was recently found to attenuate opiate analgesia. In the present study, the role of endogenous cholecystokinin in opiate analgesia was examined. Endogenously released cholecystokinin was sequestered by antibodies to cholecystokinin developed in response to an active immunization procedure. Morphine analgesia was potentiated and prolonged in rats immunized against cholecystokinin. The rate of development of morphine tolerance, however, was not affected by the antibodies. Endogenous cholecystokinin appears to function as a short-term modulator of opiate action.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nutrition in the Elderly.
J. E. Morley, A. D. Mooradian, A. J. Silver, D. Heber, and R. B. Alfin-Slater (1988)
Ann Intern Med 109, 890-904
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