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Science 7 December 1984:
Vol. 226. no. 4679, pp. 1197 - 1199
DOI: 10.1126/science.6095451
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Articles

Science, Vol 226, Issue 4679, 1197-1199
Copyright © 1984 by American Association for the Advancement of Science

articles

Requirement for a signal sequence in biological expression of the v-sis oncogene

M Hannink and DJ Donoghue

The protein encoded by the simian sarcoma virus oncogene (v-sis) contains a signal sequence, derived from the envelope gene of the parental retrovirus, which is required for transformation. Removal of the proposed signal sequence was correlated with loss of biological activity. This activity was restored to inactive deletion mutants by fusion with the coding region for a heterologous signal sequence. Biological activity of v-sis was also abolished by either a small deletion within the coding region of the signal sequence or by a point mutation introduced by site-directed mutagenesis.


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