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Science 30 November 1984:
Vol. 226. no. 4678, pp. 1092 - 1094
DOI: 10.1126/science.6494927
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Articles

Science, Vol 226, Issue 4678, 1092-1094
Copyright © 1984 by American Association for the Advancement of Science

articles

Selective deficits in the sense of smell caused by chemical modification of the olfactory epithelium

Mason JR, L Clark, and TH Morton

A chemically selective procedure for covalent modification of Schiff base-forming binding sites in proteins is demonstrated in vitro. In vivo studies show that the same procedure produces a selective anosmia ("odor blindness") when applied to the olfactory epithelia of experimental animals. Surgical experiments confirm that the sense of smell is specifically affected.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)