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Science 23 November 1984:
Vol. 226. no. 4677, pp. 985 - 987
DOI: 10.1126/science.6505679
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Articles
Science, Vol 226, Issue 4677, 985-987
Copyright © 1984 by American Association for the Advancement of Science
Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain
GO Ivy,
F Schottler,
J Wenzel,
M Baudry,
and
G Lynch
Injections of leupeptin (a thiol proteinase inhibitor) or chloroquine (a general lysosomal enzyme inhibitor) into the brains of young rats induced the formation of lysosome-associated granular aggregates (dense bodies) which closely resembled the ceroid-lipofuscin that accumulates in certain disease states and during aging. The dense material increased in a dose- and time-dependent fashion and was differentially distributed across brain regions and cell types. These observations provide clues to the origins of ceroid-lipofuscin and suggest means for studying the consequences of its accumulation.
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