Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 23 November 1984:
Vol. 226. no. 4677, pp. 979 - 982
DOI: 10.1126/science.6095446
Prev | Table of Contents | Next

Articles

Science, Vol 226, Issue 4677, 979-982
Copyright © 1984 by American Association for the Advancement of Science

articles

A single troponin T gene regulated by different programs in cardiac and skeletal muscle development

TA Cooper and CP Ordahl

A cloned complementary DNA derived from a messenger RNA transiently present at low abundance levels in early chick embryonic skeletal muscle hybridizes to a messenger RNA present at high abundance levels in cardiac muscle. Genomic DNA hybridization and nucleotide sequence identity of complementary DNA's from both heart and skeletal muscle demonstrate that the messenger RNA's from both sources are encoded by the same gene. The encoded polypeptide is a troponin T sequence which is probably a cardiac isoform. This single copy troponin T isogene is governed by different regulatory programs in heart and skeletal muscle differentiation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Multiple molecular forms of circulating cardiac troponin: analytical and clinical significance.
D. C Gaze and P. O Collinson (2008)
Ann Clin Biochem 45, 349-355
   Abstract »    Full Text »    PDF »
Expression and functional properties of four slow skeletal troponin T isoforms in rat muscles.
P. Kischel, B. Bastide, M. Muller, F. Dubail, F. Offredi, J. P. Jin, Y. Mounier, and J. Martial (2005)
Am J Physiol Cell Physiol 289, C437-C443
   Abstract »    Full Text »    PDF »
Characterization of Troponin T Dilated Cardiomyopathy Mutations in the Fetal Troponin Isoform.
G. Venkatraman, A. V. Gomes, W. G. L. Kerrick, and J. D. Potter (2005)
J. Biol. Chem. 280, 17584-17592
   Abstract »    Full Text »    PDF »
Muscle-Specific Splicing of a Heterologous Exon Mediated by a Single Muscle-Specific Splicing Enhancer from the Cardiac Troponin T Gene.
T. A. Cooper (1998)
Mol. Cell. Biol. 18, 4519-4525
   Abstract »    Full Text »
Disruption of Splicing Regulated by a CUG-Binding Protein in Myotonic Dystrophy.
A. V. Philips, L. T. Timchenko, and T. A. Cooper (1998)
Science 280, 737-741
   Abstract »    Full Text »
To T or Not to T, That Is the Question.
P. O. Collinson (1997)
Clin. Chem. 43, 421-423
   Full Text »    PDF »
The Role of Transcription Enhancer Factor-1 (TEF-1) Related Proteins in the Formation of M-CAT Binding Complexes in Muscle and Non-muscle Tissues.
I. K. G. Farrance and C. P. Ordahl (1996)
J. Biol. Chem. 271, 8266-8274
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)