Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 16 November 1984:
Vol. 226. no. 4676, pp. 857 - 860
DOI: 10.1126/science.6093257
Prev | Table of Contents | Next

Articles

Science, Vol 226, Issue 4676, 857-860
Copyright © 1984 by American Association for the Advancement of Science

articles

Benzodiazepine receptor synthesis and degradation by neurons in culture

LA Borden, C Czajkowski, CY Chan, and DH Farb

The benzodiazepine-gamma-aminobutyric acid receptor complex was used to study functional receptor synthesis and degradation in primary cultures of neurons. Fifty percent of the receptors turned over with an unusually rapid half-life (4 hours); this was followed by a second, slower phase (32 hours). These results provide the basis for elucidating the mechanism by which neurons derived from the central nervous system control neurotransmitter receptor number, an important problem in cellular neurobiology. The findings may be of significance in the study of neurological and psychiatric disorders.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Status Epilepticus Increases the Intracellular Accumulation of GABAA Receptors.
H. P. Goodkin, J.-L. Yeh, and J. Kapur (2005)
J. Neurosci. 25, 5511-5520
   Abstract »    Full Text »    PDF »
GABA Induces Activity Dependent Delayed-onset Uncoupling of GABA/Benzodiazepine Site Interactions in Neocortical Neurons.
M. C. Gravielle, R. Faris, S. J. Russek, and D. H. Farb (2005)
J. Biol. Chem. 280, 20954-20960
   Abstract »    Full Text »    PDF »
Cell Surface Stability of gamma -Aminobutyric Acid Type A Receptors. DEPENDENCE ON PROTEIN KINASE C ACTIVITY AND SUBUNIT COMPOSITION.
C. N. Connolly, J. T. Kittler, P. Thomas, J. M. Uren, N. J. Brandon, T. G. Smart, and S. J. Moss (1999)
J. Biol. Chem. 274, 36565-36572
   Abstract »    Full Text »    PDF »
Acute Pentylenetetrazol Injection Reduces Rat GABAA Receptor mRNA Levels and GABA Stimulation of Benzodiazepine Binding with No Effect on Benzodiazepine Binding Site Density.
L. A. Walsh, M. Li, T.-J. Zhao, T. H. Chiu, and H. C. Rosenberg (1999)
J. Pharmacol. Exp. Ther. 289, 1626-1633
   Abstract »    Full Text »
Repression of gamma -Aminobutyric Acid Type A Receptor alpha 1 Polypeptide Biosynthesis Requires Chronic Agonist Exposure.
J. D. Miranda and E. M. Barnes Jr. (1997)
J. Biol. Chem. 272, 16288-16294
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)