Science 16 November 1984: Vol. 226. no. 4676, pp. 850 - 852 DOI: 10.1126/science.6093256

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Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance.

M. Chen, T.-J. Lu, X.-J. Chen, Y. Zhou, Q. Chen, X.-Y. Feng, L. Xu, W.-H. Duan, and Z.-Q. Xiong (2008)
Stroke 39, 3042-3048
 |  Abstract »  |  Full Text »  |  PDF »

Localized Loss of Ca2+ Homeostasis in Neuronal Dendrites Is a Downstream Consequence of Metabolic Compromise during Extended NMDA Exposures.

T. A. Vander Jagt, J. A. Connor, and C. W. Shuttleworth (2008)
J. Neurosci. 28, 5029-5039
 |  Abstract »  |  Full Text »  |  PDF »

PDZ Protein Interactions Underlying NMDA Receptor-Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors.

H. Cui, A. Hayashi, H.-S. Sun, M. P. Belmares, C. Cobey, T. Phan, J. Schweizer, M. W. Salter, Y. T. Wang, R. A. Tasker, et al. (2007)
J. Neurosci. 27, 9901-9915
 |  Abstract »  |  Full Text »  |  PDF »

Hypoxia Suppresses Glutamate Transport in Astrocytes.

M. Dallas, H. E. Boycott, L. Atkinson, A. Miller, J. P. Boyle, H. A. Pearson, and C. Peers (2007)
J. Neurosci. 27, 3946-3955
 |  Abstract »  |  Full Text »  |  PDF »

Transient Receptor Potential Channels of the Melastatin Family and Ischemic Responses of Central Neurons.

J. F. MacDonald and M. F. Jackson (2007)
Stroke 38, 665-669
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous Activation of Adenosine A1 Receptors Accelerates Ischemic Suppression of Spontaneous Electrocortical Activity.

A. Ilie, D. Ciocan, A.-M. Zagrean, D. A. Nita, L. Zagrean, and M. Moldovan (2006)
J Neurophysiol 96, 2809-2814
 |  Abstract »  |  Full Text »  |  PDF »

Acidotoxicity trumps excitotoxicity in ischemic brain..

R. P. Simon (2006)
Arch Neurol 63, 1368-1371
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Both Early and Delayed Treatment with Melanocortin 4 Receptor-Stimulating Melanocortins Produces Neuroprotection in Cerebral Ischemia.

D. Giuliani, C. Mioni, D. Altavilla, S. Leone, C. Bazzani, L. Minutoli, A. Bitto, M.-M. Cainazzo, H. Marini, D. Zaffe, et al. (2006)
Endocrinology 147, 1126-1135
 |  Abstract »  |  Full Text »  |  PDF »

Anoxic depolarization of rat hippocampal slices is prevented by thiopental but not by propofol or isoflurane.

R. Sasaki, K. Hirota, S. H. Roth, and M. Yamazaki (2005)
Br. J. Anaesth. 94, 486-491
 |  Abstract »  |  Full Text »  |  PDF »

Hippocampal Volume in Adult Burn Patients With and Without Posttraumatic Stress Disorder.

H. Winter and E. Irle (2004)
Am J Psychiatry 161, 2194-2200
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Striatal NR2B-Containing N-Methyl-D-Aspartate Receptor-Mediated Synaptic Currents in a Mouse Model of Huntington Disease.

L. Li, T. H. Murphy, M. R. Hayden, and L. A. Raymond (2004)
J Neurophysiol 92, 2738-2746
 |  Abstract »  |  Full Text »  |  PDF »

Critical Role of Calpain-mediated Cleavage of Calcineurin in Excitotoxic Neurodegeneration.

H.-Y. Wu, K. Tomizawa, Y. Oda, F.-Y. Wei, Y.-F. Lu, M. Matsushita, S.-T. Li, A. Moriwaki, and H. Matsui (2004)
J. Biol. Chem. 279, 4929-4940
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Switches Deciding the Death of Injured Neurons.

P. Nicotera (2003)
Toxicol. Sci. 74, 4-9
 |  Abstract »  |  Full Text »  |  PDF »

epsilon PKC Is Required for the Induction of Tolerance by Ischemic and NMDA-Mediated Preconditioning in the Organotypic Hippocampal Slice.

A. P. Raval, K. R. Dave, D. Mochly-Rosen, T. J. Sick, and M. A. Perez-Pinzon (2003)
J. Neurosci. 23, 384-391
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous Dopamine Amplifies Ischemic Long-Term Potentiation via D1 Receptors.

E. Saulle, D. Centonze, A. B. Martin, R. Moratalla, G. Bernardi, and P. Calabresi (2002)
Stroke 33, 2978-2984
 |  Abstract »  |  Full Text »  |  PDF »

Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice.

S. Parmentier-Batteur, K. Jin, X. O. Mao, L. Xie, and D. A. Greenberg (2002)
J. Neurosci. 22, 9771-9775
 |  Abstract »  |  Full Text »  |  PDF »

Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions.

M. Aarts, Y. Liu, L. Liu, S. Besshoh, M. Arundine, J. W. Gurd, Y.-T. Wang, M. W. Salter, and M. Tymianski (2002)
Science 298, 846-850
 |  Abstract »  |  Full Text »  |  PDF »

Post-ischaemic long-term synaptic potentiation in the striatum: a putative mechanism for cell type-specific vulnerability.

P. Calabresi, E. Saulle, D. Centonze, A. Pisani, G. A. Marfia, and G. Bernardi (2002)
Brain 125, 844-860
 |  Abstract »  |  Full Text »  |  PDF »

Aptiganel Hydrochloride in Acute Ischemic Stroke: A Randomized Controlled Trial.

G. W. Albers, L. B. Goldstein, D. Hall, L. M. Lesko, and for the Aptiganel Acute Stroke Investigators (2001)
JAMA 286, 2673-2682
 |  Abstract »  |  Full Text »  |  PDF »

Reduction of ischemic spinal cord injury by dextrorphan: Comparison of several methods of administration.

H. Terada, T. Kazui, M. Takinami, K. Yamashita, N. Washiyama, and B. A. H. Muhammad (2001)
J. Thorac. Cardiovasc. Surg. 122, 979-985
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Synaptic NMDA Receptors by Action Potential-Dependent Release of Transmitter during Hypoxia Impairs Recovery of Synaptic Transmission on Reoxygenation.

A. M. Sebastiao, A. de Mendonca, T. Moreira, and J. A. Ribeiro (2001)
J. Neurosci. 21, 8564-8571
 |  Abstract »  |  Full Text »  |  PDF »

Complestatin Is a Noncompetitive Peptide Antagonist of N-Methyl-D-aspartate and alpha -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/Kainate Receptors: Secure Blockade of Ischemic Neuronal Death.

S. Y. Seo, B.-S. Yun, I.-J. Ryoo, J.-S. Choi, C.-K. Joo, S.-Y. Chang, J.-M. Chung, S. Oh, B. J. Gwag, and I. D. Yoo (2001)
J. Pharmacol. Exp. Ther. 299, 377-384
 |  Abstract »  |  Full Text »  |  PDF »

Two distinct oscillatory states determined by the NMDA receptor in rat inferior olive.

D. G Placantonakis and J. P Welsh (2001)
J. Physiol. 534, 123-140
 |  Abstract »  |  Full Text »  |  PDF »

An N-methyl-D-aspartate receptor channel blocker with neuroprotective activity.

K.-K. Tai, S. E. Blondelle, J. M. Ostresh, R. A. Houghten, and M. Montal (2001)
PNAS 98, 3519-3524
 |  Abstract »  |  Full Text »  |  PDF »

High Level Calcineurin Activity Predisposes Neuronal Cells to Apoptosis.

A. Asai, J.-h. Qiu, Y. Narita, S. Chi, N. Saito, N. Shinoura, H. Hamada, Y. Kuchino, and T. Kirino (1999)
J. Biol. Chem. 274, 34450-34458
 |  Abstract »  |  Full Text »  |  PDF »

Neuroprotective Effect of High Glucose Against NMDA, Free Radical, and Oxygen-Glucose Deprivation through Enhanced Mitochondrial Potentials.

S. Y. Seo, E. Y. Kim, H. Kim, and B. J. Gwag (1999)
J. Neurosci. 19, 8849-8855
 |  Abstract »  |  Full Text »  |  PDF »

Ischemic Cell Death in Brain Neurons.

P. Lipton (1999)
Physiol Rev 79, 1431-1568
 |  Abstract »  |  Full Text »  |  PDF »

Differential Expression of Brain-Derived Neurotrophic Factor, Neurotrophin-3, and Neurotrophin-4/5 in the Adult Rat Spinal Cord: Regulation by the Glutamate Receptor Agonist Kainic Acid.

I. A. Scarisbrick, P. J. Isackson, and A. J. Windebank (1999)
J. Neurosci. 19, 7757-7769
 |  Abstract »  |  Full Text »  |  PDF »

Chronic Interleukin-6 Alters NMDA Receptor-Mediated Membrane Responses and Enhances Neurotoxicity in Developing CNS Neurons.

Z. Qiu, D. D. Sweeney, J. G. Netzeband, and D. L. Gruol (1998)
J. Neurosci. 18, 10445-10456
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Acidity Potentiates AMPA Receptor-Mediated Cortical Neuronal Death.

J. W. McDonald, T. Bhattacharyya, S. L. Sensi, D. Lobner, H. S. Ying, L. M.T. Canzoniero, and D. W. Choi (1998)
J. Neurosci. 18, 6290-6299
 |  Abstract »  |  Full Text »  |  PDF »

AMPA Receptors: Players in Calcium-Mediated Neuronal Injury?.

H. L. Gaspary (1998)
Neuroscientist 4, 149-153
 |  Abstract »  |  PDF »

Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity.

V. G. Kimonides, N. H. Khatibi, C. N. Svendsen, M. V. Sofroniew, and J. Herbert (1998)
PNAS 95, 1852-1857
 |  Abstract »  |  Full Text »  |  PDF »

Ca2+-Activated K+ Currents in Rat Locus Coeruleus Neurons Induced by Experimental Ischemia, Anoxia, and Hypoglycemia.

Y. Murai, H. Ishibashi, S. Koyama, and N. Akaike (1997)
J Neurophysiol 78, 2674-2681
 |  Abstract »  |  Full Text »  |  PDF »

Topical Review: Glutamate in Neurologic Diseases.

P. Bittigau and C. Ikonomidou (1997)
J Child Neurol 12, 471-485
 |  Abstract »  |  PDF »

PROTECTION OF RAT SPINAL CORD FROM ISCHEMIA WITH DEXTRORPHAN AND CYCLOHEXIMIDE: EFFECTS ON NECROSIS AND APOPTOSIS.

H. Kato, G. K. Kanellopoulos, S. Matsuo, Y. J. Wu, M. F. Jacquin, C. Y. Hsu, D. W. Choi, and N. T. Kouchoukos (1997)
J. Thorac. Cardiovasc. Surg. 114, 609-618
 |  Abstract »  |  Full Text »

Acetylsalicylic Acid Increases Tolerance Against Hypoxic and Chemical Hypoxia.

M. W. Riepe, K. Kasischke, and A. Raupach (1997)
Stroke 28, 2006-2011
 |  Abstract »  |  Full Text »

Secondary Activation of a Cation Conductance Is Responsible for NMDA Toxicity in Acutely Isolated Hippocampal Neurons.

Q. X. Chen, K. L. Perkins, D. W. Choi, and R. K. S. Wong (1997)
J. Neurosci. 17, 4032-4036
 |  Abstract »  |  Full Text »  |  PDF »

Glial Cell Line-Derived Neurotrophic Factor Protects against Ischemia-Induced Injury in the Cerebral Cortex.

Y. Wang, S.-Z. Lin, A.-L. Chiou, L. R. Williams, and B. J. Hoffer (1997)
J. Neurosci. 17, 4341-4348
 |  Abstract »  |  Full Text »  |  PDF »

Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor.

S. A. Lipton, W.-K. Kim, Y.-B. Choi, S. Kumar, D. M. D'Emilia, P. V. Rayudu, D. R. Arnelle, and J. S. Stamler (1997)
PNAS 94, 5923-5928
 |  Abstract »  |  Full Text »  |  PDF »

Potentiation of Oxygen-Glucose Deprivation–Induced Neuronal Death After Induction of iNOS.

S. J. Hewett, J. K. Muir, D. Lobner, A. Symons, D. W. Choi, M. A. Moskowitz, and C. Ayata (1996)
Stroke 27, 1586-1591
 |  Abstract »  |  Full Text »

TGF-ß1 Protects Hippocampal Neurons Against Degeneration Caused by Transient Global Ischemia: Dose-Response Relationship and Potential Neuroprotective Mechanisms.

P. Henrich-Noack, J.H.M. Prehn, J. Krieglstein, and K. G Peters (1996)
Stroke 27, 1609-1615
 |  Abstract »  |  Full Text »

Inhibitory Effect of MS-153 on Elevated Brain Glutamate Level Induced by Rat Middle Cerebral Artery Occlusion.

K. Umemura, T. Gemba, A. Mizuno, M. Nakashima, and K. G Peters (1996)
Stroke 27, 1624-1628
 |  Abstract »  |  Full Text »

Neuroexcitatory Amino Acids and Their Relation to Infarct Size and Neurological Deficit in Ischemic Stroke.

J. Castillo, A. Davalos, J. Naveiro, and M. Noya (1996)
Stroke 27, 1060-1065
 |  Abstract »  |  Full Text »

Ketamine Antagonizes Nitric Oxide Release From Cerebral Cortex After Middle Cerebral Artery Ligation in Rats.

S.-Z. Lin, A.-L. Chiou, and Y. Wang (1996)
Stroke 27, 747-752
 |  Abstract »  |  Full Text »

Baclofen in the Treatment of Polymyoclonus and Ataxia in a Patient With Homocystinuria.

Y. Awaad, C. Sansaricq, J. Moroney, I. Fish, A. Kyriakakos, and S. E. Snyderman (1995)
J Child Neurol 10, 294-296
 |  Abstract »  |  PDF »

Delayed Antagonism of Calpain Reduces Excitotoxicity in Cultured Neurons.

J. R. Brorson, C. J. Marcuccilli, and R. J. Miller (1995)
Stroke 26, 1259-1267
 |  Abstract »  |  Full Text »

REVIEW {blacksquare} : Neuroprotection in Brain Ischemia: An Update (Part I.

M. D. Ginsberg (1995)
Neuroscientist 1, 95-103
 |  Abstract »  |  PDF »

Neuroprotective Properties of the Novel Antiepileptic Lamotrigine in a Gerbil Model of Global Cerebral Ischemia.

R. P. Wiard, M. C. Dickerson, O. Beek, R. Norton, and B. R. Cooper (1995)
Stroke 26, 466-472
 |  Abstract »  |  Full Text »

Mannitol, Dextromethorphan, and Catalase Minimize Ischemic Damage to Retinal Pigment Epithelium and Retina.

L. Y. Gupta and M. F. Marmor (1993)
Arch Ophthalmol 111, 384-388
 |  Abstract »  |  PDF »

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes.

H. Monyer, R. Sprengel, R. Schoepfer, A. Herb, M. Higuchi, H. Lomeli, N. Burnashev, B. Sakmann, and P. H. Seeburg (1992)
Science 256, 1217-1221
 |  Abstract »  |  PDF »

Do NMDA Antagonists Prevent Neuronal Injury? No..

A. M. Buchan (1992)
Arch Neurol 49, 420-421
 |  Abstract »  |  PDF »

Prevention and management of stroke.

J. C Grotta (1991)
Vascular Medicine 2, 3-17
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Limitation of Retinal Injury by Vitreoperfusion Initiated After Onset of Ischemia.

N. P. Blair, W. E. Shaw, R. Dunn Jr, Y. Tsukahara, C. Floro, and M. M. Rusin (1991)
Arch Ophthalmol 109, 113-118
 |  Abstract »  |  PDF »

The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity.

J. Weiss, D. Hartley, J Koh, and D. Choi (1990)
Science 247, 1474-1477
 |  Abstract »  |  PDF »

Comparison of the Neuroprotective Effects of the N-Methyl-D-Aspartate Antagonist MK-801 and the Opiate-Receptor Antagonist Nalmefene in Experimental Spinal Cord Ischemia.

S. W. Yum and A. I. Faden (1990)
Arch Neurol 47, 277-281
 |  Abstract »  |  PDF »

Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons.

P Sah, S Hestrin, and R. Nicoll (1989)
Science 246, 815-818
 |  Abstract »  |  PDF »

Ketamine and Retinal Ischemia.

A. C. Bird and M. J. Lavin (1989)
Arch Ophthalmol 107, 1419-1420
 |  Abstract »  |  PDF »

Selective Vulnerability of the Brain: New Insights into the Pathophysiology of Stroke.

R. C. Collins, B. H. Dobkin, and D. W. Choi (1989)
Ann Intern Med 110, 992-1000
 |  Abstract »  |  PDF »

The role of excitatory amino acids and NMDA receptors in traumatic brain injury.

A. Faden, P Demediuk, S. Panter, and R Vink (1989)
Science 244, 798-800
 |  Abstract »  |  PDF »

Indole-2-carboxylic acid: a competitive antagonist of potentiation by glycine at the NMDA receptor.

J. Huettner (1989)
Science 243, 1611-1613
 |  Abstract »  |  PDF »

Excitotoxins: A Possible New Mechanism for the Pathogenesis of Ischemic Retinal Damage.

G. H. Bresnick (1989)
Arch Ophthalmol 107, 339-341
 |  Abstract »  |  PDF »

Dextromethorphan Protects Retina Against Ischemic Injury In Vivo.

Y. H. Yoon and M. F. Marmor (1989)
Arch Ophthalmol 107, 409-411
 |  Abstract »  |  PDF »

Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity.

P. Sonsalla, W. Nicklas, and R. Heikkila (1989)
Science 243, 398-400
 |  Abstract »  |  PDF »

Intensification of Stroke Therapy?: Koroshetz W. Intensification of stroke therapy? J Intensive Care Med 1988;3:241-242.

W. Koroshetz (1988)
J Intensive Care Med 3, 241-242
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Analytic Reviews : Potential New Therapies for Acute Ischemic Stroke.

L. R. Wechsler (1988)
J Intensive Care Med 3, 258-264
 |  Abstract »  |  PDF »

Coma Following Cardiac Arrest: A Review of the Clinical Features, Management, and Prognosis.

K. Maiese and J. J. Caronna (1988)
J Intensive Care Med 3, 153-163
 |  Abstract »  |  PDF »

Glutamate Antagonist Therapy Reduces Neurologic Deficits Produced by Focal Central Nervous System Ischemia.

A. Kochhar, J. A. Zivin, P. D. Lyden, and V. Mazzarella (1988)
Arch Neurol 45, 148-153
 |  Abstract »  |  PDF »

Rat brain N-methyl-D-aspartate receptors expressed in Xenopus oocytes.

T. Verdoorn, N. Kleckner, and R Dingledine (1987)
Science 238, 1114-1116
 |  Abstract »  |  PDF »

Thrombolysis and Stroke: Past and Future.

M. A. Sloan (1987)
Arch Neurol 44, 748-768
 |  Abstract »  |  PDF »

Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons.

S Peters, J Koh, and D. Choi (1987)
Science 236, 589-593
 |  Abstract »  |  PDF »

Drug may protect brains of heart attack victims.

D. Barnes (1987)
Science 235, 632-633
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Delayed transneuronal death of substantia nigra neurons prevented by gamma-aminobutyric acid agonist.

M Saji and D. Reis (1987)
Science 235, 66-69
 |  Abstract »  |  PDF »

Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity.

J. Koh, S Peters, and D. Choi (1986)
Science 234, 73-76
 |  Abstract »  |  PDF »

The Role of Glutamate in Neurotransmission and in Neurologic Disease.

J. T. Greenamyre (1986)
Arch Neurol 43, 1058-1063
 |  Abstract »  |  PDF »

Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist.

T Wieloch (1985)
Science 230, 681-683
 |  Abstract »  |  PDF »

Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications.

R. Sapolsky and W. Pulsinelli (1985)
Science 229, 1397-1400
 |  Abstract »  |  PDF »

The Protein-tyrosine Phosphatase PTPMEG Interacts with Glutamate Receptor delta 2 and epsilon Subunits.

K. Hironaka, H. Umemori, T. Tezuka, M. Mishina, and T. Yamamoto (2000)
J. Biol. Chem. 275, 16167-16173
 |  Abstract »  |  Full Text »  |  PDF »

Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL.

A. J. Carter, M. Grauert, U. Pschorn, W. D. Bechtel, C. Bartmann-Lindholm, Y. Qu, T. Scheuer, W. A. Catterall, and T. Weiser (2000)
PNAS 97, 4944-4949
 |  Abstract »  |  Full Text »  |  PDF »

Impairment of synaptic transmission by transient hypoxia in hippocampal slices: Improved recovery in glutathione peroxidase transgenic mice.

D. Furling, O. Ghribi, A. Lahsaini, M.-E. Mirault, and G. Massicotte (2000)
PNAS 97, 4351-4356
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms for maintaining extracellular glutamate levels in the anoxic turtle striatum.

S. L. Milton, J. W. Thompson, and P. L. Lutz (2002)
Am J Physiol Regulatory Integrative Comp Physiol 282, R1317-R1323
 |  Abstract »  |  Full Text »  |  PDF »

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