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Science 16 November 1984:
Vol. 226. no. 4676, pp. 843 - 844
DOI: 10.1126/science.6494915
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Articles

Science, Vol 226, Issue 4676, 843-844
Copyright © 1984 by American Association for the Advancement of Science

articles

Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity

LH Hurley, VL Reynolds, DH Swenson, GL Petzold, and TA Scahill

Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.
K. Kiakos, A. Sato, T. Asao, P. J. McHugh, M. Lee, and J. A. Hartley (2007)
Mol. Cancer Ther. 6, 2708-2718
   Abstract »    Full Text »    PDF »
Saccharomyces cerevisiae RAD5 Influences the Excision Repair of DNA Minor Groove Adducts.
K. Kiakos, T. T. Howard, M. Lee, J. A. Hartley, and P. J. McHugh (2002)
J. Biol. Chem. 277, 44576-44581
   Abstract »    Full Text »    PDF »
Potent inhibition of Werner and Bloom helicases by DNA minor groove binding drugs.
R. M. Brosh Jr, J. K. Karow, E. J. White, N. D. Shaw, I. D. Hickson, and V. A. Bohr (2000)
Nucleic Acids Res. 28, 2420-2430
   Abstract »    Full Text »    PDF »
Inhibition of Initiation of Simian Virus 40DNA Replication in Infected BSC-1 Cells by the DNA Alkylating Drug Adozelesin.
R. J. Cobuzzi Jr., W. C. Burhans, and T. A. Beerman (1996)
J. Biol. Chem. 271, 19852-19859
   Abstract »    Full Text »    PDF »


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