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Science 9 November 1984:
Vol. 226. no. 4675, pp. 701 - 703
DOI: 10.1126/science.6494905
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Articles

Science, Vol 226, Issue 4675, 701-703
Copyright © 1984 by American Association for the Advancement of Science

articles

Detection of high molecular weight forms of platelet-derived growth factor by sequence-specific antisera

HL Niman, RA Houghten, and DF Bowen-Pope

Antisera to synthetic peptides representing sequences of both chains of platelet-derived growth factor (PDGF) were used to structurally analyze PDGF isolated from outdated human platelets and PDGF-like proteins in normal and transformed cells. Most PDGF isolated from platelets did not contain the carboxyl portion of PDGF-2 in contrast to p20sis, the major form of p28sis detected in simian sarcoma virus-transformed cells. In addition, higher molecular weight forms of molecules containing PDGF-1 and PDGF-2 sequences were detected in all cell lines tested. These lines were heterogeneous with respect to species, cell type, and transforming agent.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)