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Science 2 November 1984:
Vol. 226. no. 4674, pp. 566 - 568
DOI: 10.1126/science.6208610
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Articles

Science, Vol 226, Issue 4674, 566-568
Copyright © 1984 by American Association for the Advancement of Science

articles

Induction of pituitary lactotrope differentiation by luteinizing hormone alpha subunit

M Begeot, FJ Hemming, PM Dubois, Y Combarnous, MP Dubois, and ML Aubert

Addition of gonadotropin releasing hormone to cultures of fetal rat pituitary induced differentiation of lactotropes as revealed by immunocytochemistry. Antiserum to luteinizing hormone (LH) (recognizing native LH), but not antiserum to LH-beta (recognizing both native LH and its beta subunit), inhibited this induction. Further addition of highly purified LH-alpha subunit in culture medium also induced lactotrope differentiation. Thus, the alpha subunit may have a specific biological activity of its own with probable practical use in clinical investigations.


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