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Science 2 November 1984:
Vol. 226. no. 4674, pp. 547 - 549
DOI: 10.1126/science.6208609
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Articles

Science, Vol 226, Issue 4674, 547-549
Copyright © 1984 by American Association for the Advancement of Science

articles

Intraneuronal substance P contributes to the severity of experimental arthritis

JD Levine, R Clark, M Devor, C Helms, MA Moskowitz, and AI Basbaum

There is evidence that substance P is a peptide neurotransmitter of some unmyelinated primary afferent nociceptors and that its release from the peripheral terminals of primary afferent fibers mediates neurogenic inflammation. The investigators examined whether substance P also contributes to the severity of adjuvant-induced arthritis, an inflammatory disease in rats. They found that, in the rat, joints that developed more severe arthritis (ankles) were more densely innervated by substance P-containing primary afferent neurons than were joints that developed less severe arthritis (knees). Infusion of substance P into the knee increased the severity of arthritis; injection of a substance P receptor antagonist did not. These results suggest a significant physiological difference between joints that develop mild and severe arthritis and indicate that release of intraneuronal substance P in joints contributes to the severity of the arthritis.


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