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Science 26 October 1984:
Vol. 226. no. 4673, pp. 464 - 466
DOI: 10.1126/science.6436973
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Articles

Science, Vol 226, Issue 4673, 464-466
Copyright © 1984 by American Association for the Advancement of Science

articles

Growth hormone-releasing factor: direct effects on growth hormone, glucose, and behavior via the brain

GS Tannenbaum

Intracerebroventricular administration of human pancreatic growth hormone-releasing factor caused a dose-dependent inhibition of growth hormone secretion, elevated plasma glucose concentrations, and produced marked behavioral and motor effects. Immunoneutralization with antiserum to somatostatin did not reverse the suppression of growth hormone. These findings suggest that hypothalamic growth hormone-releasing factor may regulate its own neurosecretion through an "ultrashort-loop" negative feedback mechanism and may have important neurotransmitter and neuromodulatory functions in the brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuroendocrine Control of Growth Hormone Secretion.
E. E. Muller, V. Locatelli, and D. Cocchi (1999)
Physiol Rev 79, 511-607
   Abstract »    Full Text »    PDF »
Effects of growth hormone-releasing factor in the brain.
W. Wehrenberg and C. Ehlers (1986)
Science 232, 1271-1273
   PDF »
Response: Effects of Growth Hormone-Releasing Factor in the Brain.
G. S. TANNENBAUM (1986)
Science 232, 1272-1273
   PDF »


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