Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 26 October 1984:
Vol. 226. no. 4673, pp. 459 - 462
DOI: 10.1126/science.6093248
Prev | Table of Contents | Next

Articles

Science, Vol 226, Issue 4673, 459-462
Copyright © 1984 by American Association for the Advancement of Science

articles

Alteration of T-cell functions by infection with HTLV-I or HTLV-II

M Popovic, N Flomenberg, DJ Volkman, D Mann, AS Fauci, B Dupont, and RC Gallo

Two functionally different types of human T-cell clones, one with helper function and two with specific activity, were infected with different isolates of HTLV-I and HLTV-II. Both types of human T cells showed alterations in specific function after infection with either of the HTLV subgroups. Before HTLV infection, the T-cell clone with helper function proliferates and provides help to B cells only in the presence of both a specific soluble antigen (keyhole limpet hemocyanin) and histocompatible antigen-presenting cells. After HTLV infection, these cells respond with increased proliferation and indiscriminant stimulation of polyclonal immunoglobulin production by B cells, regardless of the histocompatibility of the antigen-presenting cells or the presence of the soluble antigen. Infection of the normal cytotoxic T-cell clones led to a dimunition or loss of the cytotoxic function. The results of these studies suggest some possible mechanisms for induction of immune deficiency and of polyclonal B-cell activation by viruses of the HTLV family.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Viral Modulation of T-Cell Receptor Signaling.
K. R. Jerome (2008)
J. Virol. 82, 4194-4204
   Full Text »    PDF »
Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens..
R. E. Mascarenhas, C. Brodskyn, G. Barbosa, J. Clarencio, A. S. Andrade-Filho, F. Figueiroa, B. Galvao-Castro, and F. Grassi (2006)
Clin. Vaccine Immunol. 13, 547-552
   Abstract »    Full Text »    PDF »
Human T Cell Lymphotropic Virus Type I (HTLV-I)-Specific CD4+ T Cells: Immunodominance Hierarchy and Preferential Infection with HTLV-I.
P. K. C. Goon, T. Igakura, E. Hanon, A. J. Mosley, A. Barfield, A. L. Barnard, L. Kaftantzi, Y. Tanaka, G. P. Taylor, J. N. Weber, et al. (2004)
J. Immunol. 172, 1735-1743
   Abstract »    Full Text »    PDF »
High Circulating Frequencies of Tumor Necrosis Factor Alpha- and Interleukin-2-Secreting Human T-Lymphotropic Virus Type 1 (HTLV-1)-Specific CD4+ T Cells in Patients with HTLV-1-Associated Neurological Disease.
P. K. C. Goon, T. Igakura, E. Hanon, A. J. Mosley, B. Asquith, K. G. Gould, G. P. Taylor, J. N. Weber, and C. R. M. Bangham (2003)
J. Virol. 77, 9716-9722
   Abstract »    Full Text »    PDF »
High frequencies of Th1-type CD4+ T cells specific to HTLV-1 Env and Tax proteins in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis.
P. K. C. Goon, E. Hanon, T. Igakura, Y. Tanaka, J. N. Weber, G. P. Taylor, and C. R. M. Bangham (2002)
Blood 99, 3335-3341
   Abstract »    Full Text »    PDF »
The contribution of oxidative stress in apoptosis of human-cultured astroglial cells induced by supernatants of HIV-1-infected macrophages.
V. Mollace, D. Salvemini, D. P. Riley, C. Muscoli, M. Iannone, T. Granato, L. Masuelli, A. Modesti, D. Rotiroti, R. Nistico, et al. (2002)
J. Leukoc. Biol. 71, 65-72
   Abstract »    Full Text »    PDF »
Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I.
P. Hollsberg (1999)
Microbiol. Mol. Biol. Rev. 63, 308-333
   Abstract »    Full Text »    PDF »
HTLV-I--associated B-cell CLL: indirect role for retrovirus in leukemogenesis.
D. Mann, P DeSantis, G Mark, A Pfeifer, M Newman, N Gibbs, M Popovic, M. Sarngadharan, R. Gallo, J Clark, et al. (1987)
Science 236, 1103-1106
   Abstract »    PDF »
Transmission of HTLV-I and HIV Among Homosexual Men in Trinidad.
C. Bartholomew, W. C. Saxinger, J. W. Clark, M. Gail, A. Dudgeon, B. Mahabir, B. Hull-Drysdale, F. Cleghorn, R. C. Gallo, and W. A. Blattner (1987)
JAMA 257, 2604-2608
   Abstract »    PDF »
Prevalence of Antibodies to HTLV-I, -II, and -III in Intravenous Drug Abusers From an AIDS Endemic Region.
M. Robert-Guroff, S. H. Weiss, J. A. Giron, A. M. Jennings, H. M. Ginzburg, I. B. Margolis, W. A. Blattner, and R. C. Gallo (1986)
JAMA 255, 3133-3137
   Abstract »    PDF »
Evidence for HTLV-I Associated With Mycosis Fungoides and B-Cell Chronic Lymphocytic Leukemia.
A. Peterman, Myles, S. Staal, Bradley, H. Striecher, J. Schupbach, and L. Resnick (1986)
Arch Dermatol 122, 568-571
   Abstract »    PDF »
A Human T-Lymphotropic Retrovirus (HTLV-III) as the Cause of the Acquired Immunodeficiency Syndrome.
R. C. GALLO and F. WONG-STAAL (1985)
Ann Intern Med 103, 679-689
   Abstract »    PDF »
Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.
J. Allan, J. Coligan, F Barin, M. McLane, J. Sodroski, C. Rosen, W. Haseltine, T. Lee, and M Essex (1985)
Science 228, 1091-1094
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)