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Science 26 October 1984:
Vol. 226. no. 4673, pp. 453 - 456
DOI: 10.1126/science.6238406
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Articles

Science, Vol 226, Issue 4673, 453-456
Copyright © 1984 by American Association for the Advancement of Science

articles

Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS

F Brun-Vezinet, C Rouzioux, L Montagnier, S Chamaret, J Gruest, F Barre-Sinoussi, D Geroldi, JC Chermann, J McCormick, S Mitchell, and al. et

The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire.


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