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Science 26 October 1984:
Vol. 226. no. 4673, pp. 443 - 445
DOI: 10.1126/science.6541806
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Articles

Science, Vol 226, Issue 4673, 443-445
Copyright © 1984 by American Association for the Advancement of Science

articles

A conformationally constrained vasopressin analog with antidiuretic antagonistic activity

G Skala, CW Smith, CJ Taylor, and JH Ludens

Application of information derived from a three-dimensional model of vasopressin bound to its antidiuretic receptor resulted in the design and synthesis of a bicyclic vasopressin analog, [5,8-cyclo(1-beta-mercaptopropionic acid,2-phenylalanine,5-aspartic acid,8-lysine)]vasopressin. The analog acts as an antagonist of the antidiuretic activity of vasopressin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structure of pressinoic acid: the cyclic moiety of vasopressin.
D. Langs, G. Smith, J. Stezowski, and R. Hughes (1986)
Science 232, 1240-1242
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