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Science 5 October 1984:
Vol. 226. no. 4670, pp. 57 - 61
DOI: 10.1126/science.6089350
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Articles

Science, Vol 226, Issue 4670, 57-61
Copyright © 1984 by American Association for the Advancement of Science

articles

Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene

TH Lee, JE Coligan, JG Sodroski, WA Haseltine, SZ Salahuddin, F Wong-Staal, RC Gallo, and M Essex

Antibodies in sera from patients with adult T-cell leukemia-lymphoma or from healthy carriers of type I human T-cell leukemia virus (HTLV) recognize an antigen of approximately 42 kilodaltons (p42) in cell lines infected with HTLV-I. Radiolabel sequence analysis of cyanogen bromide fragments of p42 led to the conclusion that this antigen is encoded in part by LOR, a conserved portion of the "X" region that is flanked by the envelope gene and the 3' long terminal repeat of HTLV-I. It is possible that this novel product mediates the unique transformation properties of the HTLV family.


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