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Science 5 October 1984:
Vol. 226. no. 4670, pp. 55 - 57
DOI: 10.1126/science.6474189
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Articles

Science, Vol 226, Issue 4670, 55-57
Copyright © 1984 by American Association for the Advancement of Science

articles

Differential development of two classes of acetylcholine receptors in Xenopus muscle in culture

RJ Leonard, S Nakajima, Y Nakajima, and T Takahashi

Physiological properties of acetylcholine receptors on muscle cells at very early stages of ontogeny were compared with those of cells at later stages. Two changes were observed that contributed to an overall shortening of the mean open time of single-channels. First, there was a shift in the relative proportions of two receptor types with different conductances and mean open times, such that the contribution of receptors with large conductance and short open time increased as development proceeded. Second, there was a sharp reduction in the mean open time of channels having small conductance, with no similar change in channels having large conductance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Functional Changes Of Fetal Muscle Acetylcholine Receptor During Mouse Development.
F. Grassi and F. Eusebi (1998)
Physiology 13, 247-251
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The open duration of fetal ACh receptor-channel changes during mouse muscle development.
F. Grassi, O. Epifano, A. M. Mileo, B. Barabino, and F. Eusebi (1998)
J. Physiol. 508, 393-400
   Abstract »    Full Text »    PDF »
Two Types of ACh Receptors Contribute to Fast Channel Gating on Mouse Skeletal Muscle.
D. Shepherd and P. Brehm (1997)
J Neurophysiol 78, 2966-2974
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