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Science 14 September 1984: Vol. 225. no. 4667, pp. 1168 - 1170 DOI: 10.1126/science.6474172
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Articles
Science, Vol 225, Issue 4667, 1168-1170
Copyright © 1984 by American Association for the Advancement of Science
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation
BT Hyman,
GW Van Hoesen,
AR Damasio,
and
CL Barnes
Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex. The affected cells are precisely those that interconnect the hippocampal formation with the association cortices, basal forebrain, thalamus, and hypothalamus, structures crucial to memory. This focal pattern of pathology isolates the hippocampal formation from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
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| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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J. Neurosci.
23, 2557-2563
| Abstract »
| Full Text »
| PDF »
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100, 1381-1386
| Abstract »
| Full Text »
| PDF »
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73, 377-384
| Abstract »
| Full Text »
| PDF »
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9, 243-252
| Abstract »
| Full Text »
| PDF »
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- C. E. Myers, A. Kluger, J. Golomb, S. Ferris, M. J. de Leon, G. Schnirman, and M. A. Gluck (2002)
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15, 82-90
| Abstract »
| PDF »
- MRI measures of entorhinal cortex vs hippocampus in preclinical AD.
- R. J. Killiany, B. T. Hyman, T. Gomez-Isla, M. B. Moss, R. Kikinis, F. Jolesz, R. Tanzi, K. Jones, and M. S. Albert (2002)
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58, 1188-1196
| Abstract »
| Full Text »
| PDF »
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- A. D. Smith (2002)
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99, 4135-4137
| Full Text »
| PDF »
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- J. S. Krasuski, G. E. Alexander, B. Horwitz, S. I. Rapoport, and M. B. Schapiro (2002)
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159, 74-81
| Abstract »
| Full Text »
| PDF »
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- R. M. Cohen, C. Small, F. Lalonde, J. Friz, and T. Sunderland (2001)
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57, 2223-2228
| Abstract »
| Full Text »
| PDF »
- Presenilin Binding Protein Is Associated with Neurofibrillary Alterations in Alzheimer's Disease and Stimulates Tau Phosphorylation.
- Q. Chen, H. Yoshida, D. Schubert, P. Maher, M. Mallory, and E. Masliah (2001)
Am. J. Pathol.
159, 1597-1602
| Abstract »
| Full Text »
| PDF »
- Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Dementias.
- Y.-Y. Hsu, A.-T. Du, N. Schuff, and M. W. Weiner (2001)
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14, 145-166
| Abstract »
| PDF »
- Selective Preservation and Degeneration Within the Prefrontal Cortex in Aging and Alzheimer Disease.
- D. H. Salat, J. A. Kaye, and J. S. Janowsky (2001)
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58, 1403-1408
| Abstract »
| Full Text »
| PDF »
- Generation of Aggregated {beta}-Amyloid in the Rat Hippocampus Impairs Synaptic Transmission and Plasticity and Causes Memory Deficits.
- A. Stephan, S. Laroche, and S. Davis (2001)
J. Neurosci.
21, 5703-5714
| Abstract »
| Full Text »
| PDF »
- Presenilin-1-associated abnormalities in regional cerebral perfusion.
- K.A. Johnson, F. Lopera, K. Jones, A. Becker, R. Sperling, J. Hilson, J. Londono, I. Siegert, M. Arcos, S. Moreno, et al. (2001)
Neurology
56, 1545-1551
| Abstract »
| Full Text »
| PDF »
- Action Potential Bursting in Subicular Pyramidal Neurons Is Driven by a Calcium Tail Current.
- H.-y. Jung, N. P. Staff, and N. Spruston (2001)
J. Neurosci.
21, 3312-3321
| Abstract »
| Full Text »
| PDF »
- Rating of Different Olfactory Judgements in Alzheimer's Disease.
- J.P. Royet, B. Croisile, R. Williamson-Vasta, O. Hibert, D. Serclerat, and J. Guerin (2001)
Chem Senses
26, 409-417
| Abstract »
| Full Text »
| PDF »
- Worsening of Post-Traumatic Stress Disorder Symptoms with Cognitive Decline: Case Series.
- D. Mittal, R. Torres, A. Abashidze, and N. Jimerson (2001)
J Geriatr Psychiatry Neurol
14, 17-20
| Abstract »
| PDF »
- Frontotemporal dementia with ubiquitinated inclusions: A case study of the regional distribution of hippocampal pathology.
- B. Mehring, J. C.Y. Lin, D. Wilson, and C. F. Lippa (2000)
American Journal of Alzheimer's Disease and Other Dementias
15, 277-283
| Abstract »
| PDF »
- Magnetization Transfer Measurements of the Hippocampus in Patients with Alzheimer's Disease, Vascular Dementia, and Other Types of Dementia.
- H. Hanyu, T. Asano, T. Iwamoto, M. Takasaki, H. Shindo, and K. Abe (2000)
AJNR Am. J. Neuroradiol.
21, 1235-1242
| Abstract »
| Full Text »
| PDF »
- Orbitofrontal Cortex Pathology in Alzheimer's Disease.
- G. W. Van Hoesen, J. Parvizi, and C.-C. Chu (2000)
Cereb Cortex
10, 243-251
| Abstract »
| Full Text »
| PDF »
- Phosphorylation of Microtubule-associated Protein Tau Is Regulated by Protein Phosphatase 2A in Mammalian Brain. IMPLICATIONS FOR NEUROFIBRILLARY DEGENERATION IN ALZHEIMER'S DISEASE.
- C.-X. Gong, T. Lidsky, J. Wegiel, L. Zuck, I. Grundke-Iqbal, and K. Iqbal (2000)
J. Biol. Chem.
275, 5535-5544
| Abstract »
| Full Text »
| PDF »
- Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients.
- D. Lütjohann, A. Papassotiropoulos, I. Björkhem, S. Locatelli, M. Bagli, R. D. Oehring, U. Schlegel, F. Jessen, M. L. Rao, K. von Bergmann, et al. (2000)
J. Lipid Res.
41, 195-198
| Abstract »
| Full Text »
- Cerebral Amyloid Induces Aberrant Axonal Sprouting and Ectopic Terminal Formation in Amyloid Precursor Protein Transgenic Mice.
- A. L. Phinney, T. Deller, M. Stalder, M. E. Calhoun, M. Frotscher, B. Sommer, M. Staufenbiel, and M. Jucker (1999)
J. Neurosci.
19, 8552-8559
| Abstract »
| Full Text »
| PDF »
- Preclinical memory decline in cognitively normal apolipoprotein E-{epsilon}4 homozygotes.
- R. J. Caselli, N. R. Graff-Radford, E. M. Reiman, A. Weaver, D. Osborne, J. Lucas, A. Uecker, and S. N. Thibodeau (1999)
Neurology
53, 201
| Abstract »
| Full Text »
- Challenging the Cholinergic Hypothesis in Alzheimer Disease.
- P. Davies (1999)
JAMA
281, 1433-1434
| Full Text »
| PDF »
- Attention and executive deficits in Alzheimer's disease: A critical review.
- R. J. Perry and J. R. Hodges (1999)
Brain
122, 383-404
| Abstract »
| Full Text »
| PDF »
- Amygdalar Volume and Emotional Memory in Alzheimer's Disease.
- E. Mori, M. Ikeda, N. Hirono, H. Kitagaki, T. Imamura, and T. Shimomura (1999)
Am J Psychiatry
156, 216-222
| Abstract »
| Full Text »
- Successful Verbal Encoding into Episodic Memory Engages the Posterior Hippocampus: A Parametrically Analyzed Functional Magnetic Resonance Imaging Study.
- G. Fernandez, H. Weyerts, M. Schrader-Bolsche, I. Tendolkar, H. G. O. M. Smid, C. Tempelmann, H. Hinrichs, H. Scheich, C. E. Elger, G. R. Mangun, et al. (1998)
J. Neurosci.
18, 1841-1847
| Abstract »
| Full Text »
| PDF »
- Gamma Oscillations in the Entorhinal Cortex of the Freely Behaving Rat.
- J. J. Chrobak and G. Buzsaki (1998)
J. Neurosci.
18, 388-398
| Abstract »
| Full Text »
| PDF »
- Life and Death of Neurons in the Aging Brain.
- J. H. Morrison and P. R. Hof (1997)
Science
278, 412-419
| Abstract »
| Full Text »
- Medial temporal structures relate to memory impairment in Alzheimer's disease: an MRI volumetric study.
- E. Mori, Y. Yoneda, H. Yamashita, N. Hirono, M. Ikeda, and A. Yamadori (1997)
J. Neurol. Neurosurg. Psychiatry
63, 214-221
| Abstract »
| Full Text »
| PDF »
- Olfactory Dysfunction for Pyridine and Dementia Progression in Alzheimer Disease.
- S. Nordin, O. Almkvist, B. Berglund, and L.-O. Wahlund (1997)
Arch Neurol
54, 993-998
| Abstract »
| PDF »
- Differential Subcellular Regulation of NMDAR1 Protein and mRNA in Dendrites of Dentate Gyrus Granule Cells after Perforant Path Transection.
- A. H. Gazzaley, D. L. Benson, G. W. Huntley, and J. H. Morrison (1997)
J. Neurosci.
17, 2006-2017
| Abstract »
| Full Text »
| PDF »
- In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain.
- K. Page, R. Hollister, R. E. Tanzi, and B. T. Hyman (1996)
PNAS
93, 14020-14024
| Abstract »
| Full Text »
| PDF »
- Estrogen Replacement Therapy and Risk of Alzheimer Disease.
- A. Paganini-Hill and V. W. Henderson (1996)
Arch Intern Med
156, 2213-2217
| Abstract »
| PDF »
- Age at Onset and Pattern of Neuropsychological Impairment in Mild Early-Stage Alzheimer Disease: A Study of a Community-Based Population.
- W. Reid, G. Broe, H. Creasey, D. Grayson, E. McCusker, H. Bennett, W. Longley, and M. R. Sulway (1996)
Arch Neurol
53, 1056-1061
| Abstract »
| PDF »
- Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F beta -Amyloid Precursor Protein and Alzheimer's Disease.
- E. Masliah, A. Sisk, M. Mallory, L. Mucke, D. Schenk, and D. Games (1996)
J. Neurosci.
16, 5795-5811
| Abstract »
| Full Text »
| PDF »
- Frontal Behavioral Syndromes in Cortical and Subcortical Dementia.
- J. S. Paulsen, J. C. Stout, J. DeLaPena, R. Romero, Z. Tawfik-Reedy, M. R. Swenson, J. Grace, P. F. Malloy, and B. Hospital (1996)
Assessment
3, 327-337
| Abstract »
- {blacksquare} REVIEW : Glutamate Receptors: Emerging Links Between Subunit Proteins and Specific Excitatory Circuits in Primate Hippocampus and Neocortex.
- J. H. Morrison, S. J. Siegel, A. H. Gazzaley, and G. W. Huntley (1996)
Neuroscientist
2, 272-283
| Abstract »
| PDF »
- Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer''s Disease.
- T. Gomez-Isla, J. L. Price, D. W. McKeel Jr., J. C. Morris, J. H. Growdon, and B. T. Hyman (1996)
J. Neurosci.
16, 4491-4500
| Abstract »
| Full Text »
| PDF »
- Contingent Vulnerability of Entorhinal Parvalbumin-Containing Neurons in Alzheimer''s Disease.
- A. Solodkin, S. D. Veldhuizen, and G. W. Van Hoesen (1996)
J. Neurosci.
16, 3311-3321
| Abstract »
| Full Text »
| PDF »
- Differentiation of the Dementias of Alzheimer's and Parkinson's Disease with the Dementia Rating Scale.
- A. M. Paolo, A. I. Troster, S. L. Glatt, J. P. Hubble, and W. C. Koller (1995)
J Geriatr Psychiatry Neurol
8, 184-188
| Abstract »
| PDF »
- Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease.
- L. M. Bierer, P. R. Hof, D. P. Purohit, L. Carlin, J. Schmeidler, K. L. Davis, and D. P. Perl (1995)
Arch Neurol
52, 81-88
| Abstract »
| PDF »
- Estrogen Replacement Therapy in Older Women: Comparisons Between Alzheimer's Disease Cases and Nondemented Control Subjects.
- V. W. Henderson, A. Paganini-Hill, C. K. Emanuel, M. E. Dunn, and J. G. Buckwalter (1994)
Arch Neurol
51, 896-900
| Abstract »
| PDF »
- Lack of Difference in Brain Hyperintensities Between Patients With Early Alzheimer's Disease and Control Subjects.
- T. Erkinjuntti, F. Gao, D. H. Lee, M. Eliasziw, H. Merskey, and V. C. Hachinski (1994)
Arch Neurol
51, 260-268
| Abstract »
| PDF »
- Evidence of Subtypes of Alzheimer's Disease and Implications for Etiology.
- W. Bondareff, C. Q. Mountjoy, C. M. Wischik, D. L. Hauser, L. D. LaBree, and M. Roth (1993)
Arch Gen Psychiatry
50, 350-356
| Abstract »
| PDF »
- Temporal Lobe Atrophy on Magnetic Resonance Imaging in the Diagnosis of Early Alzheimer's Disease.
- T. Erkinjuntti, D. H. Lee, F. Gao, R. Steenhuis, M. Eliasziw, R. Fry, H. Merskey, and V. C. Hachinski (1993)
Arch Neurol
50, 305-310
| Abstract »
| PDF »
- Topography of Cross-sectional and Longitudinal Glucose Metabolic Deficits in Alzheimer's Disease: Pathophysiologic Implications.
- G. S. Smith, M. J. de Leon, A. E. George, A. Kluger, N. D. Volkow, T. McRae, J. Golomb, S. H. Ferris, B. Reisberg, J. Ciaravino, et al. (1992)
Arch Neurol
49, 1142-1150
| Abstract »
| PDF »
- Detection and Staging of Dementia in Alzheimer's Disease: Use of the Neuropsychological Measures Developed for the Consortium to Establish a Registry for Alzheimer's Disease.
- K. A. Welsh, N. Butters, J. P. Hughes, R. C. Mohs, and A. Heyman (1992)
Arch Neurol
49, 448-452
| Abstract »
| PDF »
- Quantitative Changes in Mesial Temporal Volume, Regional Cerebral Blood Flow, and Cognition in Alzheimer's Disease.
- G. D. Pearlson, G. J. Harris, R. E. Powers, P. E. Barta, E. E. Camargo, G. A. Chase, J. T. Noga, and L. E. Tune (1992)
Arch Gen Psychiatry
49, 402-408
| Abstract »
| PDF »
- The medial temporal lobe memory system.
- L. Squire and S Zola-Morgan (1991)
Science
253, 1380-1386
| Abstract »
| PDF »
- Temporal and Hippocampal Metabolic Rate During an Olfactory Memory Task Assessed by Positron Emission Tomography in Patients With Dementia of the Alzheimer Type and Controls: Preliminary Studies.
- M. S. Buchsbaum, J. P. Kesslak, G. Lynch, H. Chui, J. Wu, N. Sicotte, E. Hazlett, E. Teng, and C. W. Cotman (1991)
Arch Gen Psychiatry
48, 840-847
| Abstract »
| PDF »
- Some Cytoarchitectural Abnormalities of the Entorhinal Cortex in Schizophrenia.
- s. E. Arnold, B. T. Hyman, G. W. Van Hoesen, and A. R. Damasio (1991)
Arch Gen Psychiatry
48, 625-632
| Abstract »
| PDF »
- Differentiation of Alzheimer's Disease and Huntington's Disease With the Dementia Rating Scale.
- D. P. Salmon, P. F. Kwo-on-Yuen, W. C. Heindel, N. Butters, and L. J. Thal (1989)
Arch Neurol
46, 1204-1208
| Abstract »
| PDF »
- Dementia: A Review Emphasizing Clinicopathologic Correlation and Brain-Behavior Relationships.
- H. C. Chui (1989)
Arch Neurol
46, 806-814
| Abstract »
| PDF »
- Commissural Connections and Symmetry of Degeneration in Alzheimer's Disease.
- S. Demeter, D. L. Rosene, and G. W. Van Hoesen (1989)
Arch Neurol
46, 723-724
| Abstract »
| PDF »
- Amyloid beta protein enhances the survival of hippocampal neurons in vitro.
- J. Whitson, D. Selkoe, and C. Cotman (1989)
Science
243, 1488-1490
| Abstract »
| PDF »
- A Verbal Memory Test With High Predictive Accuracy for Dementia of the Alzheimer Type.
- D. S. Knopman and S. Ryberg (1989)
Arch Neurol
46, 141-145
| Abstract »
| PDF »
- Alzheimer Disease: Clinical and Biological Heterogeneity.
- R. P. Friedland, E. Koss, J. V. Haxby, C. L. Grady, J. Luxenberg, M. B. Schapiro, and J. Kaye (1988)
Ann Intern Med
109, 298-311
| Abstract »
| PDF »
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