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Science 14 September 1984:
Vol. 225. no. 4667, pp. 1162 - 1165
DOI: 10.1126/science.6474170
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Articles

Science, Vol 225, Issue 4667, 1162-1165
Copyright © 1984 by American Association for the Advancement of Science

articles

A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells

A Kasid, JS Strobl, K Huff, GL Greene, and ME Lippman

Nuclear estrogen receptor from MCF-7 cells undergoes a time-dependent, hormone-inducible transformation to a form that is less extractable from nuclei and less exchangeable with ligand. This receptor-modifying, intranuclear event is independent of receptor loss (processing) and appears associated with hormone responsiveness (progesterone-receptor induction) in these cells. The magnitude of receptor loss, however, is variable and apparently not a prerequisite for hormone action to induce progesterone receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Endocrine and Intracrine Sources of Androgens in Women: Inhibition of Breast Cancer and Other Roles of Androgens and Their Precursor Dehydroepiandrosterone.
F. Labrie, V. Luu-The, C. Labrie, A. Belanger, J. Simard, S.-X. Lin, and G. Pelletier (2003)
Endocr. Rev. 24, 152-182
   Abstract »    Full Text »    PDF »
Suppression of Ligand-Dependent Estrogen Receptor Activity by Bone-Resorbing Cytokines in Human Osteoblasts.
P. V. N. Bodine, H. A. Harris, and B. S. Komm (1999)
Endocrinology 140, 2439-2451
   Abstract »    Full Text »
Hirsutism.
R. S. RITTMASTER and D. L. LORIAUX (1987)
Ann Intern Med 106, 95-107
   Abstract »    PDF »
Transfection of v-rasH DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity.
A Kasid, M. Lippman, A. Papageorge, D. Lowy, and E. Gelmann (1985)
Science 228, 725-728
   Abstract »    PDF »


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