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Science 31 August 1984:
Vol. 225. no. 4665, pp. 943 - 947
DOI: 10.1126/science.6089336
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Articles

Science, Vol 225, Issue 4665, 943-947
Copyright © 1984 by American Association for the Advancement of Science

articles

Distinctive termini characterize two families of human endogenous retroviral sequences

PE Steele, AB Rabson, T Bryan, and MA Martin

Human DNA contains many copies of endogenous retroviral sequences. Characterization of molecular clones of these structures reveals the existence of two related families. One family consists of full-length (8.8 kilobases) proviral structures, with typical long terminal repeates (LTR's). The other family consists of structures, which contain only 4.1 kilobases of gag-pol sequences, bounded by a tandem array of imperfect repeats 72 to 76 base pairs in length. Typical LTR sequences that exist as solitary elements in the genome were cloned and characterized.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structure and Phylogenetic Analysis of an Endogenous Retrovirus Inserted into the Human Growth Factor Gene Pleiotrophin.
A. M. Schulte and A. Wellstein (1998)
J. Virol. 72, 6065-6072
   Abstract »    Full Text »    PDF »
Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus.
A. M. Schulte, S. Lai, A. Kurtz, F. Czubayko, A. T. Riegel, and A. Wellstein (1996)
PNAS 93, 14759-14764
   Abstract »    Full Text »    PDF »


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