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Science 31 August 1984:
Vol. 225. no. 4665, pp. 930 - 932
DOI: 10.1126/science.6382606
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Articles

Science, Vol 225, Issue 4665, 930-932
Copyright © 1984 by American Association for the Advancement of Science

articles

Growth self-incitement in murine melanoma B16: a phenomenological model

Z Bajzer, K Pavelic, and S Vuk-Pavlovic

The growing murine melanoma B16 secretes increasing quantities of a substance or substances immunologically cross-reactive with insulin. The elevated concentrations of these substances in blood are accompanied by a decrease in blood glucose concentration and release of growth hormone, which is followed by increased tumor growth. By use of a phenomenological model based on these data, we show that B16 incites its own growth by positive feedback.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)