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Science 24 August 1984:
Vol. 225. no. 4664, pp. 847 - 849
DOI: 10.1126/science.6474156
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Articles

Science, Vol 225, Issue 4664, 847-849
Copyright © 1984 by American Association for the Advancement of Science

articles

Enhancement of sexual motivation in male rats by yohimbine

JT Clark, ER Smith, and JM Davidson

Yohimbine hydrochloride, an alpha 2-adrenoceptor antagonist, increased sexual motivation in male rats as evidenced by increased mounting performance in mating tests conducted after genital anesthetization, increased percentage of male rats ejaculating in their first heterosexual encounter, and induction of copulatory behavior in sexually inactive male rats. These observations lead to the suggestion that alpha-adrenoceptors are important modulators of sexual arousal in intact male rats. These results indicate that pharmacological treatment of sexual (libido) dysfunction may be useful.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effects of Antisense to the {alpha}2A-Adrenoceptors Administered into the Region of the Locus Ceruleus on Behaviors in Plus-Maze and Sexual Behavior Tests in Sham-Operated and Castrated Male Rats.
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J. Neurosci. 21, 726-731
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Design and Evaluation of Nitrosylated alpha -Adrenergic Receptor Antagonists as Potential Agents for the Treatment of Impotence.
I. S. de Tejada, D. S. Garvey, J. D. Schroeder, T. Shelekhin, L. G. Letts, A. Fernández, B. Cuevas, S. Gabancho, V. Martínez, J. Angulo, et al. (1999)
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{alpha}2Adrenergic and Opiate Receptor Blockade: Synergistic Effects on Anxiety in Healthy Subjects.
D. S. Charney and G. R. Heninger (1986)
Arch Gen Psychiatry 43, 1037-1041
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