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Science 17 August 1984:
Vol. 225. no. 4663, pp. 733 - 734
DOI: 10.1126/science.6205449
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Articles

Science, Vol 225, Issue 4663, 733-734
Copyright © 1984 by American Association for the Advancement of Science

articles

Learned histamine release

M Russell, KA Dark, RW Cummins, G Ellman, E Callaway, and HV Peeke

Most of the effort directed at understanding the problems of allergy has focused on the interacting components of the immune system. The possibility that histamine may be released as a learned response has now been tested. In a classical conditioning procedure in which an immunologic challenge was paired with the presentation of an odor, guinea pigs showed a plasma histamine increase when presented with the odor alone. This suggests that the immune response can be enhanced through activity of the central nervous system.


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