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Science 17 August 1984:
Vol. 225. no. 4663, pp. 718 - 721
DOI: 10.1126/science.6463648
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Articles

Science, Vol 225, Issue 4663, 718-721
Copyright © 1984 by American Association for the Advancement of Science

articles

Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene

H Persson and P Leder

Antisera to the human cellular myc oncogene product were used to identify a human c-myc specific protein with a molecular weight of 65,000. Subcellular fractionation showed that the human c-myc protein is predominantly found in the cell nucleus. The p65Kc-myc protein binds to double- and single-stranded DNA as measured by a DNA affinity chromatography assay.


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Expression of HGF, Its Receptor c-met, c-myc, and Albumin in Cirrhotic and Neoplastic Human Liver Tissue.
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The Role of myc Oncogenes in Cell Growth and Differentiation.
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The human myc gene family: structure and activity of L-myc and an L-myc pseudogene..
R A DePinho, K S Hatton, A Tesfaye, G D Yancopoulos, and F W Alt (1987)
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Expression of a homeo domain protein in noncontact-inhibited cultured cells and postmitotic neurons..
W F Odenwald, C F Taylor, F J Palmer-Hill, V Friedrich, M Tani, and R A Lazzarini (1987)
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Activation and repression of mammalian gene expression by the c-myc protein..
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Early signals in the mitogenic response.
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Science 234, 161-166
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Identification and characterization of the protein encoded by the human N-myc oncogene.
D. Slamon, T. Boone, R. Seeger, D. Keith, V Chazin, H. Lee, and L. Souza (1986)
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The Human myc Gene Family.
F.W. Alt, R. DePinho, K. Zimmerman, E. Legouy, K. Hatton, P. Ferrier, A. Tesfaye, G. Yancopoulos, and P. Nisen (1986)
Cold Spring Harb Symp Quant Biol 51, 931-941
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Colocalization of the myc Oncogene Protein and Small Nuclear Ribonucleoprotein Particles.
N.F. Sullivan, R.A. Watt, M.R. Delannoy, C.L. Green, and D.L. Spector (1986)
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Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I.
W. Goh, J Sodroski, C Rosen, M Essex, and W. Haseltine (1985)
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Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor.
B. Cochran, J Zullo, I. Verma, and C. Stiles (1984)
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Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation.
H Persson, L Hennighausen, R Taub, W DeGrado, and P Leder (1984)
Science 225, 687-693
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