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Science 17 August 1984:
Vol. 225. no. 4663, pp. 716 - 718
DOI: 10.1126/science.6087453
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Articles

Science, Vol 225, Issue 4663, 716-718
Copyright © 1984 by American Association for the Advancement of Science

articles

Lymphoma in macaques: association with virus of human T lymphotrophic family

T Homma, PJ Kanki, NW King Jr, RD Hunt, MJ O'Connell, NL Letvin, MD Daniel, RC Desrosiers, CS Yang, and M Essex

Human T-cell leukemia virus has been linked with adult T-cell leukemia-lymphoma (ATLL), a tumor of mature T cells that occurs at elevated rates in southwestern Japan and in the Caribbean Basin. Human T-cell leukemia virus (HTLV) or a closely related virus, has also been found in varying proportions of healthy individuals of several species of Old World monkeys. In the present study, conducted with macaques from Taiwan and the New England Regional Primate Research Center, antibodies to membrane antigens of HTLV-infected cells (HTLV-MA) were found in 11 of 13 macaques with malignant lymphoma or lymphoproliferative disease but in only 7 of 95 of healthy macaques. This indicates that antibodies to HTLV are significantly associated with the development of naturally occurring lymphoid neoplasms in at least some species of nonhuman primates.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
African Origin of Human T-Lymphotropic Virus Type 2 (HTLV-2) Supported by a Potential New HTLV-2d Subtype in Congolese Bambuti Efe Pygmies.
A.-M. Vandamme, M. Salemi, M. Van Brussel, H.-F. Liu, K. Van Laethem, M. Van Ranst, L. Michels, J. Desmyter, and P. Goubau (1998)
J. Virol. 72, 4327-4340
   Abstract »    Full Text »    PDF »
Detection of Infectious Simian Immunodeficiency Virus in B- and T-Cell Lymphomas of Experimentally Infected Macaques.
M. T. Maggiorella, F. Monardo, M. L. Koanga-Mogtomo, L. Cioe, L. Sernicola, F. Corrias, C. D. Baroni, P. Verani, and F. Titti (1998)
Blood 91, 3103-3111
   Abstract »    Full Text »    PDF »
New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM).
P. Kanki, F Barin, S M'Boup, J. Allan, J. Romet-Lemonne, R Marlink, M. McLane, T. Lee, B Arbeille, F Denis, et al. (1986)
Science 232, 238-243
   Abstract »    PDF »
Isolation of T-lymphotropic retrovirus related to HTLV-III/LAV from wild-caught African green monkeys.
P. Kanki, J Alroy, and M Essex (1985)
Science 230, 951-954
   Abstract »    PDF »
Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III.
P. Kanki, M. McLane, N. King Jr, N. Letvin, R. Hunt, P Sehgal, M. Daniel, R. Desrosiers, and M Essex (1985)
Science 228, 1199-1201
   Abstract »    PDF »
Isolation of T-cell tropic HTLV-III-like retrovirus from macaques.
M. Daniel, N. Letvin, N. King, M Kannagi, P. Sehgal, R. Hunt, P. Kanki, M Essex, and R. Desrosiers (1985)
Science 228, 1201-1204
   Abstract »    PDF »
Antibody to Human T-Lymphotropic Virus Type III in Wives of Hemophiliacs: Evidence for Heterosexual Transmission.
J. K. KREISS, L. W. KITCHEN, H. E. PRINCE, C. K. KASPER, and M. ESSEX (1985)
Ann Intern Med 102, 623-626
   Abstract »    PDF »


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