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Science 17 August 1984:
Vol. 225. no. 4663, pp. 682 - 687
DOI: 10.1126/science.6463646
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Articles

Science, Vol 225, Issue 4663, 682-687
Copyright © 1984 by American Association for the Advancement of Science

articles

Criteria for evidence of chemical carcinogenicity. Interdisciplinary Panel on Carcinogenicity

The Interdisciplinary Panel on Carcinogenicity reviewed and reevaluated criteria for assessing evidence of carcinogenicity of chemical substances. The panel reviewed criteria applicable to data derived from human epidemiological studies and from both in vivo and in vitro laboratory studies. A critical appraisal of all these sources of information led to the conclusion that the characterization of human risk always requires interdisciplinary evaluation of the entire array of data on a case-by-case basis. Animal studies, whenever possible, should be augmented by studies of mechanisms, metabolism, and pharmacodynamics. Such studies may assist in assessing risk to man. Recognizing the utility of such data should point the way for better assessment in the future.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Why Not Use Sensible Criteria for Assessing the Carcinogenicity for Indoor Air Pollutants.
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Indoor and Built Environment 1, 119-122
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Yes, But Is It a Human Carcinogen?.
A. Furst (1990)
International Journal of Toxicology 9, 1-18
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Carcinogenicity of Chemicals: The Weight of Evidence.
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Human and Experimental Toxicology 7, 411-418
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Detection of a cellular oncogene in spontaneous liver tumors of B6C3F1 mice.
T. Fox and P. Watanabe (1985)
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