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Science 10 August 1984:
Vol. 225. no. 4662, pp. 641 - 643
DOI: 10.1126/science.6740332
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Articles

Science, Vol 225, Issue 4662, 641-643
Copyright © 1984 by American Association for the Advancement of Science

articles

Calcium source for excitation-contraction coupling in myocardium of nonhibernating and hibernating chipmunks

N Kondo and S Shibata

The amplitude of the early plateau phase of the action potential and the slow action potential of cardiac muscle were much lower in hibernating chipmunks than in nonhibernating chipmunks. The frequency-dependent contraction was decreased in hibernating animals but increased in nonhibernating animals. Caffeine caused a negative inotropic effect in hibernating animals but a positive inotropic effect in nonhibernating animals. Ryanodine caused greater inhibition in hibernating animals than in nonhibernating animals. These results suggest that the respective roles of the sources of calcium for cardiac excitation-contraction coupling are changed during hibernation.


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