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Science 3 August 1984:
Vol. 225. no. 4661, pp. 521 - 523
DOI: 10.1126/science.6377497
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Articles

Science, Vol 225, Issue 4661, 521-523
Copyright © 1984 by American Association for the Advancement of Science

articles

A model study of fecapentaenes: mutagens of bacterial origin with alkylating properties

I Gupta, K Suzuki, RW Bruce, JJ Krepinsky, and P Yates

Fecapentaene-14 and -12 are directly acting mutagens that do not require metabolic activation. Their unusual structure suggests a possible mechanism of action. A carbocation that is formed by the addition of an electrophilic species (such as a proton) to the enol ether is most probably the reactive species. A series of model enol ethers with conjugated systems of various lengths was prepared, and a correlation between mutagenicity and increasing reactivity of derived carbocations was found. The glycerol moiety does not play a crucial role in the overall reactivity of the fecapentaenes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Elevated Lipid Peroxidation in Rats Induced by Dietary Lipids and N-Nitrosodimethylamine and its Inhibition by Indomethacin Monitored Via Ethane Exhalation.
E. Hietanen, M. Ahotupa, J.-C. Bereziat, V. Bussacchini, A.-M. Camus, and H. Bartsch (1987)
Toxicol Pathol 15, 93-96
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