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Science 27 July 1984:
Vol. 225. no. 4660, pp. 430 - 432
DOI: 10.1126/science.6429854
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Articles

Science, Vol 225, Issue 4660, 430-432
Copyright © 1984 by American Association for the Advancement of Science

articles

Intestinal uptake and metabolism of auranofin, a new oral gold-based antiarthritis drug

K Tepperman, R Finer, S Donovan, RC Elder, J Doi, D Ratliff, and K Ng

Auranofin, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S-(triethy lphosphine)- gold(I), an experimental antiarthritis pharmaceutical, metabolized in contact with hamster or rat gut wall to yield the deacetylated form of the drug. This product, 1-thio-beta-D-glucopyranosato-S-(triethylphosphine)gold(I), passed through hamster or rat intestinal wall in an everted gut experiment. The metabolite was separated by high-performance liquid chromatography and characterized by retention time, chemical reactivity to yield a known product, and comparison to a synthetic sample of the metabolite.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)