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Science 20 July 1984:
Vol. 225. no. 4659, pp. 324 - 326
DOI: 10.1126/science.6234658

Articles

Science, Vol 225, Issue 4659, 324-326
Copyright © 1984 by American Association for the Advancement of Science


articles

The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone

CE Seidman, AD Duby, E Choi, RM Graham, E Haber, C Homcy, JA Smith, and JG Seidman

The structure of rat preproatrial natriuretic factor ( preproANF ) was determined by nucleotide sequence analysis of an ANF complementary DNA clone. PreproANF is composed of a hydrophobic leader segment (20 amino acids), a precursor containing one glycosylation site (106 amino acids), and ANF (24 amino acids). Atrial natriuretic factor is located at the carboxyl terminus of the precursor molecule. The human, mouse, and rat genomes each contain a single ANF gene which is highly conserved.


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