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Science 6 July 1984:
Vol. 225. no. 4657, pp. 69 - 72
DOI: 10.1126/science.6328663
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Articles

Science, Vol 225, Issue 4657, 69-72
Copyright © 1984 by American Association for the Advancement of Science

articles

Lymphadenopathy associated virus infection of a blood donor--recipient pair with acquired immunodeficiency syndrome

PM Feorino, VS Kalyanaraman, HW Haverkos, CD Cabradilla, DT Warfield, HW Jaffe, AK Harrison, MS Gottlieb, D Goldfinger, JC Chermann, and al. et

A retrovirus isolated from three patients with the acquired immunodeficiency syndrome (AIDS) in the United States was morphologically and antigenically identical to lymphadenopathy associated virus isolated in France. Two of these isolates were from a blood donor-recipient pair, each of whom developed AIDS. Lymphadenopathy associated virus was isolated from the blood donor's lymphocytes 12 months after his onset of AIDS symptoms and from the blood recipient's lymphocytes 1 month after her onset of AIDS symptoms. Two isolates from the blood donor-recipient pair and an isolate from an epidemiologically unrelated homosexual man were examined by competitive radioimmunoassay to determine their antigenic relatedness to each other and to other human retroviruses. The major core proteins (p25) of the isolates were antigenically identical and all three isolates were identical to prototype lymphadenopathy associated virus isolated in France.


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