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Science 6 July 1984:
Vol. 225. no. 4657, pp. 57 - 59
DOI: 10.1126/science.6587566
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Articles

Science, Vol 225, Issue 4657, 57-59
Copyright © 1984 by American Association for the Advancement of Science

articles

High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11

RV Lebo, F Gorin, RJ Fletterick, FT Kao, MC Cheung, BD Bruce, and YW Kan

A rapid gene-mapping system uses a high-resolution, dual-laser sorter to identify genes from separate human chromosomes prepared with a new stain combination. This system was used to sort 21 unique chromosome types onto nitrocellulose filter papers. Several labeled gene probes hybridized to the sorted chromosomal DNA types predicted by their previous chromosome assignments. The skeletal muscle glycogen phosphorylase gene was then mapped to a portion of chromosome 11 by spot blotting normal and translocated chromosomes.


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The Effect of Oral Sucrose on Exercise Tolerance in Patients with McArdle's Disease.
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Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system.
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Flow Karyotyping and Sorting of Human Chromosomes.
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Flow-sorting Analysis of Normal and Abnormal Human Genomes.
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Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.
W. Leonard, T. Donlon, R. Lebo, and W. Greene (1985)
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Inducible and Developmental Control of Neuroendocrine Genes.
R.M. Evans, C. Weinberger, S. Hollenberg, L. Swanson, C. Nelson, and M.G. Rosenfeld (1985)
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