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Science 29 June 1984:
Vol. 224. no. 4656, pp. 1438 - 1440
DOI: 10.1126/science.6427926
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Articles

Science, Vol 224, Issue 4656, 1438-1440
Copyright © 1984 by American Association for the Advancement of Science

articles

1,25-dihydroxyvitamin D3: a novel immunoregulatory hormone

CD Tsoukas, DM Provvedini, and SC Manolagas

The hormonal form of vitamin D3, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], at picomolar concentrations, inhibited the growth-promoting lymphokine interleukin-2, which is produced by human T lymphocytes activated in vitro by the mitogen phytohemagglutinin. Other metabolites of vitamin D3 were less effective than 1,25(OH)2D3 in suppressing interleukin-2; their order of potency corresponded to their respective affinity for the 1,25(OH)2D3 receptor, suggesting that the effect on interleukin-2 was mediated by this specific receptor. The proliferation of mitogen-activated lymphocytes was also inhibited by 1,25(OH)2D3. This effect of the hormone became more pronounced at later stages of the culture. These findings demonstrate that 1,25(OH)2D3 is an immunoregulatory hormone.


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