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Science 15 June 1984:
Vol. 224. no. 4654, pp. 1243 - 1245
DOI: 10.1126/science.6732895
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Articles

Science, Vol 224, Issue 4654, 1243-1245
Copyright © 1984 by American Association for the Advancement of Science

articles

Insect prothoracicotropic hormone: evidence for two molecular forms

WE Bollenbacher, EJ Katahira, M O'Brien, LI Gilbert, MK Thomas, N Agui, and AH Baumhover

In an insect, the tobacco hornworm Manduca sexta, the cerebral neuropeptide prothoracicotropic hormone (PTTH), the primary effector of postembryonic development, exists as two molecular forms. These two PTTH's elicit characteristic in vitro dose responses of activation of prothoracic glands from different developmental stages, an indication that during development the glands change in their sensitivity to the neurohormones. Both PTTH's are active in a specific in situ bioassay. Since they may be released in situ at stage-specific times to evoke distinctly different developmental responses, the PTTH neuroendocrine axis appears to be an effective system for determining the functions of molecular forms of a neurohormone in the regulation of growth and development.


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PNAS 101, 1601-1606
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Purification and characterization of the prothoracicotropic hormone of Drosophila melanogaster.
A.-J. Kim, G.-H. Cha, K. Kim, L. I. Gilbert, and C. C. Lee (1997)
PNAS 94, 1130-1135
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