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Science 8 June 1984:
Vol. 224. no. 4653, pp. 1113 - 1115
DOI: 10.1126/science.6372098
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Articles

Science, Vol 224, Issue 4653, 1113-1115
Copyright © 1984 by American Association for the Advancement of Science

articles

Organ-specific adhesion of metastatic tumor cells in vitro

PA Netland and BR Zetter

Binding of tumor cells to cryostat sections of host organs was studied. B16-F10 melanoma cells and reticulum cell sarcoma cells demonstrated an organ specificity in their binding in vitro that reflected the organ specificity of their metastatic distribution 25 days after intravenous injection. These results provide evidence for specific binding of tumor cells to the tissues that they selectively colonize in vivo.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of Sialic Acid Incorporation Prevents Hepatic Metastases.
H. E. Wagner, P. Thomas, B. C. Wolf, A. Rapoza, and G. Steele Jr (1990)
Arch Surg 125, 351-354
   Abstract »    PDF »
Experimental Liver Metastasis: Implications of Clonal Proclivity and Organ Specificity.
T. S. Ravikumar, J. D'Emilia, C. Cocchiaro, B. Wolf, V. King, and G. Steele Jr (1989)
Arch Surg 124, 49-54
   Abstract »    PDF »


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