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Science 8 June 1984:
Vol. 224. no. 4653, pp. 1111 - 1113
DOI: 10.1126/science.6609433
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Articles

Science, Vol 224, Issue 4653, 1111-1113
Copyright © 1984 by American Association for the Advancement of Science

articles

Synthesis of a cyclic melanotropic peptide exhibiting both melanin-concentrating and -dispersing activities

BC Wilkes, VJ Hruby, AM Castrucci, WC Sherbrooke, and ME Hadley

A putative melanin-concentrating hormone was synthesized. This peptide, H-Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val-OH , stimulates melanin granule aggregation within teleost melanocytes at nanomolar concentrations as does the natural purified teleost pituitary preparation. In addition, this peptide stimulates melanin granule dispersion within melanocytes of frogs and lizards. The peptide has about one six-hundredth of the activity of alpha-melanocyte-stimulating hormone on frog and lizard melanocytes and is a full agonist.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
SLC-1 Receptor Mediates Effect of Melanin-Concentrating Hormone on Feeding Behavior in Rat: A Structure-Activity Study.
T. Suply, O. Della Zuana, V. Audinot, M. Rodriguez, P. Beauverger, J. Duhault, E. Canet, J.-P. Galizzi, J.-L. Nahon, N. Levens, et al. (2001)
J. Pharmacol. Exp. Ther. 299, 137-146
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