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Science 8 June 1984:
Vol. 224. no. 4653, pp. 1107 - 1109
DOI: 10.1126/science.6144184
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Articles

Science, Vol 224, Issue 4653, 1107-1109
Copyright © 1984 by American Association for the Advancement of Science

articles

Epidermal growth factor immunoreactive material in the central nervous system: location and development

JH Fallon, KB Seroogy, SE Loughlin, RS Morrison, RA Bradshaw, DJ Knaver, and DD Cunningham

Epidermal growth factor (EGF) is a potent mitogen with hormonal activity in the gastrointestinal tract. Material cross-reacting with EGF was detected in the central nervous system of the developing and adult albino rat by the indirect immunofluorescence technique. High concentrations of EGF-cross-reacting material were identified in forebrain and midbrain structures of pallidal areas of the brain. These include the globus pallidus, ventral pallidum, entopeduncular nucleus, substantia nigra pars reticulata, and the islands of Calleja . Thus, EGF may represent another gut-brain peptide with potential neurotransmitter-neuromodulator functions in pallidal structures of the extrapyramidal motor systems of the brain.


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