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Science 8 June 1984:
Vol. 224. no. 4653, pp. 1104 - 1106
DOI: 10.1126/science.6719135
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Articles

Science, Vol 224, Issue 4653, 1104-1106
Copyright © 1984 by American Association for the Advancement of Science

articles

Chromosomal location of human metallothionein genes: implications for Menkes' disease

CJ Schmidt, DH Hamer, and OW McBride

Human metallothioneins are encoded by a complex multigene family. The chromosomal location of these genes has been determined by gel transfer hybridization analysis of the DNA from human-rodent cell hybrids. Chromosome 16 contains a cluster of metallothionein sequences, including two functional metallothionein I genes and a functional metallothionein II gene. The remaining sequences, including a processed pseudogene, are dispersed to at least four other autosomes. The absence of metallothionein sequences from the X chromosome indicates that Menkes' disease, an X-linked disorder of copper metabolism, affects metallothionein expression by a trans-acting mechanism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of Copper Metabolism in the Mottled Mouse.
S. Packman (1987)
Arch Dermatol 123, 1545-1547a
   Abstract »    PDF »
Metallothionein Gene Regulation in Menkes' Syndrome.
D. H. Hamer (1987)
Arch Dermatol 123, 1384a-1385a
   Abstract »    PDF »
A novel human gene closely related to the abl proto-oncogene.
G. Kruh, C. King, M. Kraus, N. Popescu, S. Amsbaugh, W. McBride, and S. Aaronson (1986)
Science 234, 1545-1548
   Abstract »    PDF »


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