Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 June 1984:
Vol. 224. no. 4652, pp. 996 - 998
DOI: 10.1126/science.6585955
Prev | Table of Contents | Next

Articles

Science, Vol 224, Issue 4652, 996-998
Copyright © 1984 by American Association for the Advancement of Science

articles

Loss of adhesion of murine erythroleukemia cells to fibronectin during erythroid differentiation

VP Patel and HF Lodish

Uninduced murine erythroleukemia cells specifically attached to fibronectin-coated dishes but not to dishes coated with laminin or type I or IV collagen. Dimethyl sulfoxide-induced differentiation of these cells caused a dramatic decrease in adhesion to fibronectin that was correlated with synthesis of the erythrocyte glycoprotein "band III," a membrane marker of the differentiated erythrocyte. Loss or modification of fibronectin binding sites on the cell surface during erythroid differentiation may cause the release of reticulocytes from the interstitial matrix of bone marrow into the blood.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system.
J. Zhang, M. Socolovsky, A. W. Gross, and H. F. Lodish (2003)
Blood 102, 3938-3946
   Abstract »    Full Text »    PDF »
Cross-talk between {alpha}4{beta}1/{alpha}5{beta}1 and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways.
R. Kapur, R. Cooper, L. Zhang, and D. A. Williams (2001)
Blood 97, 1975-1981
   Abstract »    Full Text »    PDF »
Specific Domains of Fibronectin Mediate Adhesion and Migration of Early Murine Erythroid Progenitors.
K. L. Goltry and V. P. Patel (1997)
Blood 90, 138-147
   Abstract »    Full Text »    PDF »
Specific pattern of gene expression during induction of mouse erythroleukemia cells..
P J Fraser and P J Curtis (1987)
Genes & Dev. 1, 855-861
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)