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Science 11 May 1984:
Vol. 224. no. 4649, pp. 619 - 621
DOI: 10.1126/science.6424235
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Articles

Science, Vol 224, Issue 4649, 619-621
Copyright © 1984 by American Association for the Advancement of Science

articles

Isolated chromaffin cells from adrenal medulla contain primarily monoamine oxidase B

MB Youdim, DK Banerjee, and HB Pollard

Cultured chromaffin cells from bovine adrenal medulla were found to contain primarily the B form of monoamine oxidase. This monoamine oxidase B enzyme was somewhat distinct from B enzymes from other sources, in that noradrenaline was a much poorer substrate than serotonin. Nonetheless, studies with selective inhibitors of the A form (clorgyline) and the B form [(-)-deprenyl] confirmed that chromaffin cell monoamine oxidase was the B form. The observation that chromaffin cell monoamine oxidase has poor affinity for catecholamines is consistent with physiological needs that require the cell to synthesize and store large amounts of catecholamines.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Production and Metabolism of Serotonin (5-HT) by the Human Adrenal Cortex: Paracrine Stimulation of Aldosterone Secretion by 5-HT.
H. Lefebvre, P. Compagnon, V. Contesse, C. Delarue, C. Thuillez, H. Vaudry, and J.-M. Kuhn (2001)
J. Clin. Endocrinol. Metab. 86, 5001-5007
   Abstract »    Full Text »    PDF »
A Key Amino Acid Responsible for Substrate Selectivity of Monoamine Oxidase A and B.
Y. Tsugeno and A. Ito (1997)
J. Biol. Chem. 272, 14033-14036
   Abstract »    Full Text »    PDF »


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