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Science 30 March 1984:
Vol. 223. no. 4643, pp. 1435 - 1437
DOI: 10.1126/science.6701530
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Articles

Science, Vol 223, Issue 4643, 1435-1437
Copyright © 1984 by American Association for the Advancement of Science

articles

Coronary arteries of cardiac patients are hyperreactive and contain stores of amines: a mechanism for coronary spasm

S Kalsner and R Richards

Coronary arteries from hearts of cardiac patients contain significantly higher concentrations of histamine than do those from noncardiac patients. The coronary vessels of cardiac patients are also hyperresponsive to histamine and serotonin. These differences between groups of patients suggest an explanation for coronary artery spasm in heart disease.


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