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Science 30 March 1984:
Vol. 223. no. 4643, pp. 1425 - 1428
DOI: 10.1126/science.6701529
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Articles

Science, Vol 223, Issue 4643, 1425-1428
Copyright © 1984 by American Association for the Advancement of Science

articles

Association of parvoviruses with rheumatoid arthritis of humans

RW Simpson, L McGinty, L Simon, CA Smith, CW Godzeski, and RJ Boyd

A small virus resembling parvoviruses in its morphological and physicochemical properties was derived from synovial tissue of a patient with severe rheumatoid arthritis. This virus, designated RA-1, elicits a syndrome in neonatal mice that includes neurological disturbances, permanent crippling of limbs, dwarfism, alopecia, blepharitis, "masking," and a rigid curvature of the thoracic spine. Polyclonal antibodies against RA-1 display high virus neutralizing activity and in immunoassays detect reactive antigen in synovial cells from different rheumatoid arthritis patients but not persons with osteoarthritis. Putative parvoviruses isolated from several other rheumatoid arthritis patients are only weakly pathogenic for newborn mice but can generate RA-1 virus-specific antigens in tissues of these animals. It has not been established that RA-1 and existing parvoviruses of mammalian species are related.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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J. R Kerr (2000)
Ann Rheum Dis 59, 672-683
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Science 254, 1010-1013
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Risks Associated With Human Parvovirus B19 Infection.
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Arch Dermatol 125, 475-480
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Risks Associated With Human Parvovirus B19 Infection.
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Accommodating Science: The Rhetorical Life of Scientific Facts.
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