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Science 23 March 1984:
Vol. 223. no. 4642, pp. 1301 - 1304
DOI: 10.1126/science.6367041
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Articles

Science, Vol 223, Issue 4642, 1301-1304
Copyright © 1984 by American Association for the Advancement of Science

articles

Insulin receptor phosphorylation may not be a prerequisite for acute insulin action

IA Simpson and JA Hedo

An antiserum to the insulin receptor mimicked insulin's acute actions on glucose transport, phosphorylation of integral membrane proteins, and internalization of the insulin receptor in isolated rat adipose cells. These insulinomimetic actions of the antiserum occurred without the equivalent increase in phosphorylation of the beta subunit of the insulin receptor observed with insulin. Thus, a role of receptor phosphorylation in acute insulin action is now questioned.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Insulin and Insulin-like Growth Factor Receptors and Responses.
R.A. Roth, G. Steele-Perkins, J. Hari, C. Stover, S. Pierce, J. Turner, J.C. Edman, and W.J. Rutter (1988)
Cold Spring Harb Symp Quant Biol 53, 537-543
   Abstract »    PDF »
After insulin binds.
O. Rosen (1987)
Science 237, 1452-1458
   Abstract »    PDF »
Insulin mediators from rat skeletal muscle have differential effects on insulin-sensitive pathways of intact adipocytes.
L Jarett, E. Wong, S. Macaulay, and J. Smith (1985)
Science 227, 533-535
   Abstract »    PDF »


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