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Science 2 March 1984:
Vol. 223. no. 4639, pp. 936 - 938
DOI: 10.1126/science.6198722
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Articles

Science, Vol 223, Issue 4639, 936-938
Copyright © 1984 by American Association for the Advancement of Science

articles

Partial characterization of 21.5K myelin basic protein from sheep brain

PR Carnegie and CA Dowse

The 21,500 molecular weight (21.5K) variant of myelin basic protein (MBP) was isolated from sheep brain and partially characterized. Digestion with cyanogen bromide and trypsin yielded peptides which showed that approximately 30 additional amino acids were inserted at the equivalent of the amino acid at position 57 in the bovine 18.5K MBP sequence. An unusually hydrophobic peptide Pro, Val, Leu, Trp, Lys was present in this region. Ornithine was present in hydrolyzates of 21.5K MBP, but it was not detected in any of the peptides.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)