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Science 17 February 1984:
Vol. 223. no. 4637, pp. 714 - 716
DOI: 10.1126/science.6320369
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Articles

Science, Vol 223, Issue 4637, 714-716
Copyright © 1984 by American Association for the Advancement of Science

articles

Susceptibility of skeletal muscle to Coxsackie A2 virus infection: effects of botulinum toxin and denervation

CG Andrew, DB Drachman, A Pestronk, and O Narayan

Coxsackie A viruses can infect denervated but not innervated mature skeletal muscles. The role of synaptic transmission in preventing susceptibility to Coxsackievirus infection was studied by surgically denervating leg muscles of mice or injecting the muscles with botulinum toxin to block quantal release of acetylcholine. Control muscles were injected with heat-inactivated toxin. Subsequent injection of Coxsackie A2 virus resulted in extensive virus replication and tissue destruction in the denervated and botulinum toxin-treated muscles, while the control muscles showed only minimal changes. This suggests that the susceptibility of skeletal muscle to Coxsackievirus infection is regulated by synaptic transmission.


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